6-(1,1-dioxido-3-oxo-6-(3,4,5-trimethoxybenzamido)benzo[d]isothiazol-2(3H)-yl)hexanoic acid

Base Information

• Chemical Name: 6-(1,1-dioxido-3-oxo-6-(3,4,5-trimethoxybenzamido)benzo[d]isothiazol-2(3H)-yl)hexanoic acid
• CAS No.: 1569314-61-9
• Molecular Formula: C₂₃H₂₆N₂O₉S
• Molecular Weight: 506.533

Synonyms:6-(1,1-dioxido-3-oxo-6-(3,4,5-trimethoxybenzamido)benzo[d]isothiazol-2(3H)-yl)hexanoic acid

Chemical Property of 6-(1,1-dioxido-3-oxo-6-(3,4,5-trimethoxybenzamido)benzo[d]isothiazol-2(3H)-yl)hexanoic acid

Chemical Property:

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Technology Process of 6-(1,1-dioxido-3-oxo-6-(3,4,5-trimethoxybenzamido)benzo[d]isothiazol-2(3H)-yl)hexanoic acid

There total 5 articles about 6-(1,1-dioxido-3-oxo-6-(3,4,5-trimethoxybenzamido)benzo[d]isothiazol-2(3H)-yl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

6-(6-amino-1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)hexanoic acid (1569314-53-9) + 3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → 6-(1,1-dioxido-3-oxo-6-(3,4,5-trimethoxybenzamido)benzo[d]isothiazol-2(3H)-yl)hexanoic acid (1569314-61-9)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 8h;

DOI:10.1016/j.bmc.2014.01.045

Reference yield:

6-nitrosaccharin (22952-24-5) → 6-(1,1-dioxido-3-oxo-6-(3,4,5-trimethoxybenzamido)benzo[d]isothiazol-2(3H)-yl)hexanoic acid (1569314-61-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 4 h / 60 - 80 °C

2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 4 h / 20 °C / 760.05 Torr

3: sodium hydrogencarbonate / tetrahydrofuran / 8 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.01.045

Reference yield:

Eudesmic acid (118-41-2) → 6-(1,1-dioxido-3-oxo-6-(3,4,5-trimethoxybenzamido)benzo[d]isothiazol-2(3H)-yl)hexanoic acid (1569314-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / 2 h / 60 °C

2: sodium hydrogencarbonate / tetrahydrofuran / 8 h / 20 °C

With thionyl chloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1016/j.bmc.2014.01.045

upstream raw materials:

6-nitrosaccharin

Eudesmic acid

6-(6-amino-1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)hexanoic acid

3,4,5-Trimethoxybenzoyl chloride

Downstream raw materials:

N-(2-(6-(hydroxyamino)-6-oxohexyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-3,4,5-trimethoxybenzamide

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