N-(9-chloro-3-methyl-7-phenyl-5H-pyrimido<4,5-d><2>-benzazepin-1-yl)-N,N-dimethyl-1,3-propanediamine

Base Information

Chemical Name:N-(9-chloro-3-methyl-7-phenyl-5H-pyrimido<4,5-d><2>-benzazepin-1-yl)-N,N-dimethyl-1,3-propanediamine
CAS No.:81993-82-0
Molecular Formula:C₂₄H₂₆ClN₅
Molecular Weight:419.957
Hs Code.:

Synonyms:N-(9-chloro-3-methyl-7-phenyl-5H-pyrimido<4,5-d><2>-benzazepin-1-yl)-N,N-dimethyl-1,3-propanediamine

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Chemical Property of N-(9-chloro-3-methyl-7-phenyl-5H-pyrimido<4,5-d><2>-benzazepin-1-yl)-N,N-dimethyl-1,3-propanediamine

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Technology Process of N-(9-chloro-3-methyl-7-phenyl-5H-pyrimido<4,5-d><2>-benzazepin-1-yl)-N,N-dimethyl-1,3-propanediamine

There total 6 articles about N-(9-chloro-3-methyl-7-phenyl-5H-pyrimido<4,5-d><2>-benzazepin-1-yl)-N,N-dimethyl-1,3-propanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 81993-76-2
1,9-dichloro-3-methyl-7-phenyl-5H-pyrimido<4,5-d><2>-benzazepine

: 109-55-7
1-amino-3-(dimethylamino)propane

: 81993-82-0
N-(9-chloro-3-methyl-7-phenyl-5H-pyrimido<4,5-d><2>-benzazepin-1-yl)-N,N-dimethyl-1,3-propanediamine

Guidance literature:: In N,N-dimethyl-formamide; at 65 ℃; for 16h;
DOI:10.1021/jo00362a007

Reference yield:

: 52728-54-8
1,1-dimethyl-2-n-propylhydrazine

: 81993-76-2
1,9-dichloro-3-methyl-7-phenyl-5H-pyrimido<4,5-d><2>-benzazepine

: 81993-82-0
N-(9-chloro-3-methyl-7-phenyl-5H-pyrimido<4,5-d><2>-benzazepin-1-yl)-N,N-dimethyl-1,3-propanediamine

Guidance literature:: With hydrogenchloride; In N-methyl-acetamide; methanol;

Reference yield:

: 81078-28-6
8-chloro-4,5-dibromo-4,5-dihydro-1-phenyl-3H-2-benzazepine

: 81993-82-0
N-(9-chloro-3-methyl-7-phenyl-5H-pyrimido<4,5-d><2>-benzazepin-1-yl)-N,N-dimethyl-1,3-propanediamine

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / KOH / 2-methyl-propan-2-ol; tetrahydrofuran / 1.25 h / Ambient temperature

3: 62 percent / phosphorous oxychloride / CH₂Cl₂ / 18 h / Ambient temperature

4: 78 percent / dimethylformamide / 16 h / 65 °C

With potassium hydroxide; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo00362a007