(2R,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoic acid pentafluorophenyl ester

Base Information

Chemical Name:(2R,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoic acid pentafluorophenyl ester
CAS No.:250039-48-6
Molecular Formula:C₂₀H₁₈F₅NO₄
Molecular Weight:431.359
Hs Code.:

Synonyms:(2R,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoic acid pentafluorophenyl ester

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Chemical Property of (2R,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoic acid pentafluorophenyl ester

Chemical Property:

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Technology Process of (2R,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoic acid pentafluorophenyl ester

There total 4 articles about (2R,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 3160-59-6,4276-05-5,28862-89-7,55723-45-0,55723-48-3,127866-12-0
N-benzyloxycarbonylamino-D-alloisoleucine

: 250039-48-6
(2R,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoic acid pentafluorophenyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ja010222c

Reference yield:

: 1509-35-9,959215-79-3,18875-42-8
D-alloisoleucine

: 250039-48-6
(2R,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 0 - 20 °C

2: EDAC*HCl; 4-dimethylaminopyridine / CH₂Cl₂ / 4.5 h / 0 - 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;
DOI:10.1021/ol9910058

Reference yield:

: 75315-63-8
N-(benzyloxycarbonyl)succinimide

: 250039-48-6
(2R,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2: EDAC*HCl; DMAP / CH₂Cl₂ / 4.5 h / 0 - 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;
DOI:10.1021/ja010222c