(4R,5S)-4-benzyloxycarbonylamino-5-methyl-3-oxo-heptanoic acid methyl ester

Base Information

Chemical Name:(4R,5S)-4-benzyloxycarbonylamino-5-methyl-3-oxo-heptanoic acid methyl ester
CAS No.:159360-04-0
Molecular Formula:C₁₇H₂₃NO₅
Molecular Weight:321.373
Hs Code.:

Synonyms:(4R,5S)-4-benzyloxycarbonylamino-5-methyl-3-oxo-heptanoic acid methyl ester

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Chemical Property of (4R,5S)-4-benzyloxycarbonylamino-5-methyl-3-oxo-heptanoic acid methyl ester

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Technology Process of (4R,5S)-4-benzyloxycarbonylamino-5-methyl-3-oxo-heptanoic acid methyl ester

There total 17 articles about (4R,5S)-4-benzyloxycarbonylamino-5-methyl-3-oxo-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 79-20-9
acetic acid methyl ester

: 3160-59-6,4276-05-5,28862-89-7,55723-45-0,55723-48-3,127866-12-0
N-benzyloxycarbonylamino-D-alloisoleucine

: 159360-04-0
(4R,5S)-4-benzyloxycarbonylamino-5-methyl-3-oxo-heptanoic acid methyl ester

Guidance literature:: With 1,1'-carbonyldiimidazole; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 2h;

Reference yield:

: 3160-59-6,4276-05-5,28862-89-7,55723-45-0,55723-48-3,127866-12-0
N-benzyloxycarbonylamino-D-alloisoleucine

: 159360-04-0
(4R,5S)-4-benzyloxycarbonylamino-5-methyl-3-oxo-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: EDAC*HCl; 4-dimethylaminopyridine / CH₂Cl₂ / 4.5 h / 0 - 20 °C

2.1: lithium diisopropylamide / tetrahydrofuran / 1 h / -78 °C

2.2: 3.42 g / tetrahydrofuran / 0.75 h / -78 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol9910058

Reference yield:

: 75315-63-8
N-(benzyloxycarbonyl)succinimide

: 159360-04-0
(4R,5S)-4-benzyloxycarbonylamino-5-methyl-3-oxo-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2: EDAC*HCl; DMAP / CH₂Cl₂ / 4.5 h / 0 - 20 °C

3: 3.42 g / tetrahydrofuran / 0.75 h / -78 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja010222c