16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(4-methylpiperazin-1-yl)-pregna-1,4-diene-3,20-dione[11β,16α(R)]

Base Information

• Chemical Name: 16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(4-methylpiperazin-1-yl)-pregna-1,4-diene-3,20-dione[11β,16α(R)]
• CAS No.: 917480-19-4
• Molecular Formula: C₃₃H₄₈N₂O₅
• Molecular Weight: 552.755
• Mol file: 917480-19-4.mol

Synonyms:16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(4-methylpiperazin-1-yl)-pregna-1,4-diene-3,20-dione[11β,16α(R)]

Chemical Property of 16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(4-methylpiperazin-1-yl)-pregna-1,4-diene-3,20-dione[11β,16α(R)]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(4-methylpiperazin-1-yl)-pregna-1,4-diene-3,20-dione[11β,16α(R)]

There total 2 articles about 16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(4-methylpiperazin-1-yl)-pregna-1,4-diene-3,20-dione[11β,16α(R)] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) + 16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-methanesulfonyloxy-pregna-1,4-diene-3,20-dione[11β,16α(R)] (917480-17-2) → 16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(4-methylpiperazin-1-yl)-pregna-1,4-diene-3,20-dione[11β,16α(R)] (917480-19-4)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃;

Reference yield:

desisobutyryl ciclesonide (161115-59-9) + 1-methyl-piperazine (109-01-3) → 16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(4-methylpiperazin-1-yl)-pregna-1,4-diene-3,20-dione[11β,16α(R)] (917480-19-4)

Guidance literature:

desisobutyryl ciclesonide; With 2,4,6-triisopropylphenylsulfonyl chloride; In pyridine; at 0 - 20 ℃; for 2h;

1-methyl-piperazine; In pyridine; at 20 ℃;

Reference yield:

16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(4-methylpiperazin-1-yl)-pregna-1,4-diene-3,20-dione[11β,16α(R)] (917480-19-4) + methanesulfonic acid 5-(2-{tert-butoxycarbonyl-[6-(4-phenyl-butoxy)-hexyl]-amino}-1-hydroxy-ethyl)-2-(di-tert-butoxy-phosphoryloxy)-benzyl ester (917480-09-2) → C71H109N3O13P(1+)*I(1-)

Guidance literature:

With sodium iodide; In acetonitrile; at 20 ℃; for 72h;

upstream raw materials:

1-methyl-piperazine

16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-methanesulfonyloxy-pregna-1,4-diene-3,20-dione[11β,16α(R)]

desisobutyryl ciclesonide