161115-59-9

Basic information

• Product Name: Desisobutyryl Ciclesonide
• Synonyms: 21-Desisobutyryl Ciclesonide;(2′R)-2′-Cyclohexyl-11b,21-dihydroxy-16bH-[1,3]dioxolo[4′,5′:16,17]pregna-1,4-diene-3,20-dione;Ciclesonide impurity B;Desisobutyryl Ciclesonide;(11β,16α)-16,17-[[(R)-CyclohexylMethylene]bis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione;CIC-AP;Ciclesonide active principle
• CAS NO: 161115-59-9
• Molecular Formula: C₂₈H₃₈O₆
• Molecular Weight: 470.59772
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 161115-59-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 129-132?C
• Boiling Point: 640.778 °C at 760 mmHg
• Flash Point: 211.522 °C
• Appearance: /
• Density: 1.284g/cm³
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 12.87±0.10(Predicted)
• CAS DataBase Reference: Desisobutyryl Ciclesonide(CAS DataBase Reference)
• NIST Chemistry Reference: Desisobutyryl Ciclesonide(161115-59-9)
• EPA Substance Registry System: Desisobutyryl Ciclesonide(161115-59-9)

Safety Data

• Hazardous Substances Data: 161115-59-9(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Uses

Preclinical profile of Ciclesonide, a novel corticosteroid for the treatment of asthma.

Upstream product

• 126544-47-6 ciclesonide 
• 91160-89-3 9α-bromo-11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate 
• 77017-20-0 16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate 
• 37413-91-5 2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate 
• 2043-61-0 cyclohexanecarbaldehyde 
• 86401-80-1 11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate 
• 13951-70-7 desonide 
• 638-94-8 desonide 

Downstream Products

• 126544-47-6 ciclesonide 
• 1451396-66-9 21-bromo-16α,17-[(R)-cyclohexylmethylenedioxy]-11β-hydroxypregna-1,4-dien-3,20-dione 
• 917480-23-0 16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(N,N-dimethylamino)-pregna-1,4-diene-3,20-dione[11β,16α(R)] 
• 1243575-79-2 C₄₂H₅₇NO₁₄ 
• 1243575-80-5 C₄₂H₅₇NO₁₄ 
• 1243575-77-0 C₄₀H₅₄O₁₃ 
• 1243575-78-1 C₄₀H₅₄O₁₃ 
• 1243575-85-0 C₃₄H₄₈O₁₀ 
• 1243575-76-9 C₅₄H₅₆O₁₉ 
• 1243575-75-8 C₃₈H₄₈O₁₅ 
• 1243575-74-7 C₅₀H₇₂O₁₅ 
• 1243575-72-5 C₅₀H₇₂O₁₅ 
• 1243575-71-4 C₄₆H₆₄O₁₅ 
• 1243575-70-3 C₄₂H₅₆O₁₅ 

Relevant articles and documents

Preparation method of ciclesonide

The invention discloses a preparation method of ciclesonide. The preparation method comprises the following steps: aldolization reaction, primary purification, hydrolysis reaction, esterification reaction and secondary purification. Aldolization reaction:

Pregnane derivatives 16, 17 - acetal (ketone) preparation method

Disclosed is a method for preparing a pregnane derivative 16,17-acetal (ketal) compound shown in the general formula I, the method comprising the step of reacting a compound of a general formula II with a compound of a general formula III or a general formula IV in the presence of boron trifluoride, wherein the dotted line between site 1 and site 2 denotes a saturated or unsaturated bond; R is hydroxyl, halogen or -OCOR7, wherein R7 is a C1-C12 linear chain or branched alkyl, a C3-C10 cycloalkyl, a C2-C8 alkenyl or a C2-C8 alkynyl; R1 and R2 are each hydrogen, a C1-C12 linear chain or branched alkyl, a C3-C10 cycloalkyl, a C2-C8 alkenyl or a C2-C8 alkynyl, or R1, R2 and the carbon to which they are connected form a C3-C10 cycloalkyl together, with the provision that R1 and R2 are not hydrogen simultaneously; R3 is hydrogen or -OCOR8, wherein R8 is a C1-C12 linear chain or branched alkyl, or a C3-C10 cycloalkyl; R4 is hydrogen, fluorine or chlorine; R5 is hydrogen, fluorine, chlorine or methyl; and R6 is a C1-C12 linear chain or branched alkyl. Compared with current processes, the method causes little pollution to the environment, has relatively mild reaction conditions, ease of control, reduced energy consumption and low production costs.

STEROID COMPOUND

A steroid compound of the Formula (1): [wherein R1 represents a group selected from the group consisting of H, CH3, C2H5, C3H7 and CH (CH3)2, R2 represents a group selected from NH2, NHAc and OCOR1, R3 represents a group selected from the group consisting of CH3, COOCH3 and CH2OCOR1.]