N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-L-prolinamide hydrochloride

Base Information

Chemical Name:N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-L-prolinamide hydrochloride
CAS No.:1269408-84-5
Molecular Formula:C₂₂H₂₃FN₄O*ClH
Molecular Weight:414.91
Hs Code.:

Synonyms:N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-L-prolinamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-L-prolinamide hydrochloride

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Technology Process of N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-L-prolinamide hydrochloride

There total 6 articles about N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-L-prolinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1269407-90-0
1,1-dimethylethyl (2S)-2-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)-1-pyrrolidinecarboxylate

: 1269408-84-5
N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-L-prolinamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1.41667h;

Reference yield:

: 179897-89-3
5-Bromo-2-fluoro-benzonitrile

: 1269408-84-5
N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-L-prolinamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 100 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: triethylamine; HATU / dichloromethane; methanol / 0.5 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 1.42 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1269408-84-5
N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-L-prolinamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 100 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: triethylamine; HATU / dichloromethane; methanol / 0.5 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 1.42 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;