1,1-dimethylethyl (2S)-2-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)-1-pyrrolidinecarboxylate

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Chemical Name:1,1-dimethylethyl (2S)-2-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)-1-pyrrolidinecarboxylate
CAS No.:1269407-90-0
Molecular Formula:C₂₇H₃₁FN₄O₃
Molecular Weight:478.567
Hs Code.:

Synonyms:1,1-dimethylethyl (2S)-2-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)-1-pyrrolidinecarboxylate

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Chemical Property of 1,1-dimethylethyl (2S)-2-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)-1-pyrrolidinecarboxylate

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Technology Process of 1,1-dimethylethyl (2S)-2-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)-1-pyrrolidinecarboxylate

There total 5 articles about 1,1-dimethylethyl (2S)-2-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1269407-87-5
4-[(3S)-3-amino-1-pyrrolidinyl]-4'-fluoro-3-biphenylcarbonitrile hydrochloride

: 1269407-90-0
1,1-dimethylethyl (2S)-2-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)-1-pyrrolidinecarboxylate

Guidance literature:: With triethylamine; HATU; In methanol; dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 179897-89-3
5-Bromo-2-fluoro-benzonitrile

: 1269407-90-0
1,1-dimethylethyl (2S)-2-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 100 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: triethylamine; HATU / dichloromethane; methanol / 0.5 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1269407-90-0
1,1-dimethylethyl (2S)-2-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 100 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: triethylamine; HATU / dichloromethane; methanol / 0.5 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;