(E)-ethyl 2-(2-benzamido-3-(furan-2-yl)-3-(methylthio)acrylamido)-3-hydroxypropanoate

Base Information

Chemical Name:(E)-ethyl 2-(2-benzamido-3-(furan-2-yl)-3-(methylthio)acrylamido)-3-hydroxypropanoate
CAS No.:1414547-44-6
Molecular Formula:C₂₀H₂₂N₂O₆S
Molecular Weight:418.47
Hs Code.:

Synonyms:(E)-ethyl 2-(2-benzamido-3-(furan-2-yl)-3-(methylthio)acrylamido)-3-hydroxypropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-ethyl 2-(2-benzamido-3-(furan-2-yl)-3-(methylthio)acrylamido)-3-hydroxypropanoate

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Technology Process of (E)-ethyl 2-(2-benzamido-3-(furan-2-yl)-3-(methylthio)acrylamido)-3-hydroxypropanoate

There total 1 articles about (E)-ethyl 2-(2-benzamido-3-(furan-2-yl)-3-(methylthio)acrylamido)-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 4117-31-1
ethyl L-serinate

: 1446782-86-0
4-[(furan-2-yl)(methylthio)methylene]-2-phenyloxazol-5(4H)-one

: 1414547-44-6
(E)-ethyl 2-(2-benzamido-3-(furan-2-yl)-3-(methylthio)acrylamido)-3-hydroxypropanoate

Guidance literature:: With acetic acid; In ethanol; regioselective reaction; Reflux;
DOI:10.1021/jo3021192

Reference yield: 73.0%

: 1414547-44-6
(E)-ethyl 2-(2-benzamido-3-(furan-2-yl)-3-(methylthio)acrylamido)-3-hydroxypropanoate

: 1414547-46-8
(2S)-ethyl 2-[5-(furan-2-yl)-2-phenyloxazole-4-carboxamido]-3-hydroxypropanoate

Guidance literature:: With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; Inert atmosphere;
DOI:10.1021/jo3021192

Reference yield:

: 1414547-44-6
(E)-ethyl 2-(2-benzamido-3-(furan-2-yl)-3-(methylthio)acrylamido)-3-hydroxypropanoate

: 1414545-89-3
C₁₉H₁₄N₂O₅

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / N,N-dimethyl-formamide / 90 °C / Inert atmosphere

2.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; Bromotrichloromethane / dichloromethane / 5 h / 0 °C

With copper(l) iodide; 1,10-Phenanthroline; Bromotrichloromethane; diethylamino-sulfur trifluoride; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo3021192