1-[3-(7-{Cyclopropyl-[(E)-2-hydroxyethoxyimino]-methyl}-imidazo[1,2-a]pyridin-3-yl)-5-isopropoxy-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea

Base Information

Chemical Name:1-[3-(7-{Cyclopropyl-[(E)-2-hydroxyethoxyimino]-methyl}-imidazo[1,2-a]pyridin-3-yl)-5-isopropoxy-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea
CAS No.:1251899-91-8
Molecular Formula:C₂₅H₂₈F₃N₅O₄
Molecular Weight:519.524
Hs Code.:

Synonyms:1-[3-(7-{Cyclopropyl-[(E)-2-hydroxyethoxyimino]-methyl}-imidazo[1,2-a]pyridin-3-yl)-5-isopropoxy-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea

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Chemical Property of 1-[3-(7-{Cyclopropyl-[(E)-2-hydroxyethoxyimino]-methyl}-imidazo[1,2-a]pyridin-3-yl)-5-isopropoxy-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea

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Technology Process of 1-[3-(7-{Cyclopropyl-[(E)-2-hydroxyethoxyimino]-methyl}-imidazo[1,2-a]pyridin-3-yl)-5-isopropoxy-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea

There total 15 articles about 1-[3-(7-{Cyclopropyl-[(E)-2-hydroxyethoxyimino]-methyl}-imidazo[1,2-a]pyridin-3-yl)-5-isopropoxy-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 3279-95-6
O-(2-hydroxyethyl)hydroxylamine

: 1251863-23-6
1-[3-(7-cyclopropanecarbonylimidazo[1,2-a]pyridin-3-yl)-5-isopropoxyphenyl]-3-(2,2,2-trifluoroethyl)urea

: 1251899-90-7
1-[3-(7-{Cyclopropyl-[(Z)-2-hydroxyethoxyimino]-methyl}-imidazo[1,2-a]pyridin-3-yl)-5-isopropoxy-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea

: 1251899-91-8
1-[3-(7-{Cyclopropyl-[(E)-2-hydroxyethoxyimino]-methyl}-imidazo[1,2-a]pyridin-3-yl)-5-isopropoxy-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea

Guidance literature:: With pyridine; In ethanol; at 70 ℃; for 120h;

Reference yield:

: 342613-80-3
7-hydroxymethylimidazo[1,2-a]pyridine

: 1251899-91-8
1-[3-(7-{Cyclopropyl-[(E)-2-hydroxyethoxyimino]-methyl}-imidazo[1,2-a]pyridin-3-yl)-5-isopropoxy-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea

Guidance literature:: Multi-step reaction with 8 steps

1: manganese(IV) oxide / dichloromethane

2: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3: manganese(IV) oxide / dichloromethane

4: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 20 °C

5: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 6 h / Inert atmosphere; Reflux

6: hydroxylamine hydrochloride; pyridine / ethanol / 50 °C

7: caesium carbonate / dimethyl sulfoxide / 1 h / 20 °C

8: water; acetic acid / tetrahydrofuran / 48 h / 20 °C

With pyridine; manganese(IV) oxide; potassium phosphate; N-iodo-succinimide; hydroxylamine hydrochloride; water; caesium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 116632-23-6
3-bromo-5-nitro-phenol

: 1251899-91-8
1-[3-(7-{Cyclopropyl-[(E)-2-hydroxyethoxyimino]-methyl}-imidazo[1,2-a]pyridin-3-yl)-5-isopropoxy-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: titanium(III) chloride / tetrahydrofuran / 48 h / 20 °C

3.1: tetrahydrofuran / 1 h / 60 °C

3.2: 12 h / 20 - 60 °C

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 10 h / 100 °C / Inert atmosphere

5.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 6 h / Inert atmosphere; Reflux

6.1: hydroxylamine hydrochloride; pyridine / ethanol / 50 °C

7.1: caesium carbonate / dimethyl sulfoxide / 1 h / 20 °C

8.1: water; acetic acid / tetrahydrofuran / 48 h / 20 °C

With pyridine; potassium phosphate; titanium(III) chloride; hydroxylamine hydrochloride; water; potassium acetate; potassium carbonate; caesium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;