1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid

Base Information

• Chemical Name: 1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid
• CAS No.: 1293980-87-6
• Molecular Formula: C₁₆H₁₂ClN₃O₄S
• Molecular Weight: 377.808
• Mol file: 1293980-87-6.mol

Synonyms:1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid

Chemical Property of 1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid

There total 6 articles about 1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-(3-(4-chlorophenyl)-4-formyl-1H-pyrazol-1-yl)benzenesulfonamide (1135953-03-5) → 1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid (1293980-87-6)

Guidance literature:

With bis(acetylacetonate)oxovanadium; dihydrogen peroxide; In water; acetonitrile; at 70 ℃; for 8h; Green chemistry;

DOI:10.1002/jhet.3546

Reference yield:

para-chloroacetophenone (99-91-2) → 1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid (1293980-87-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium acetate / water

1.2: 1 h / Reflux

2.1: trichlorophosphate / 5 h / 55 - 60 °C

3.1: methanol; sodium hydroxide / tetrahydrofuran / 14 h / 20 °C

3.2: Cooling

4.1: pyridine; potassium permanganate / water / 20 °C

4.2: 0.5 h

With pyridine; methanol; potassium permanganate; sodium acetate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; water;

DOI:10.1016/j.ejmech.2011.01.060

Reference yield:

C14H14ClN3O2S (363597-29-9) → 1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid (1293980-87-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate / 5 h / 55 - 60 °C

2.1: methanol; sodium hydroxide / tetrahydrofuran / 14 h / 20 °C

2.2: Cooling

3.1: pyridine; potassium permanganate / water / 20 °C

3.2: 0.5 h

With pyridine; methanol; potassium permanganate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; water;

DOI:10.1016/j.ejmech.2011.01.060

upstream raw materials:

C₁₄H₁₄ClN₃O₂S

C₁₉H₁₇ClN₄O₃S

4-(3-(4-chlorophenyl)-4-formyl-1H-pyrazol-1-yl)benzenesulfonamide

para-chloroacetophenone

Downstream raw materials:

4-[3-(4-chlorophenyl)-4-(hydrazinocarbonyl)-1H-pyrazole-1-yl]benzenesulfonamide

methyl 1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylate