4-[3-(4-chlorophenyl)-4-(hydrazinocarbonyl)-1H-pyrazole-1-yl]benzenesulfonamide

Base Information

• Chemical Name: 4-[3-(4-chlorophenyl)-4-(hydrazinocarbonyl)-1H-pyrazole-1-yl]benzenesulfonamide
• CAS No.: 1583315-62-1
• Molecular Formula: C₁₆H₁₄ClN₅O₃S
• Molecular Weight: 391.838
• Mol file: 1583315-62-1.mol

Synonyms:4-[3-(4-chlorophenyl)-4-(hydrazinocarbonyl)-1H-pyrazole-1-yl]benzenesulfonamide

Chemical Property of 4-[3-(4-chlorophenyl)-4-(hydrazinocarbonyl)-1H-pyrazole-1-yl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(4-chlorophenyl)-4-(hydrazinocarbonyl)-1H-pyrazole-1-yl]benzenesulfonamide

There total 3 articles about 4-[3-(4-chlorophenyl)-4-(hydrazinocarbonyl)-1H-pyrazole-1-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylate (1583315-55-2) → 4-[3-(4-chlorophenyl)-4-(hydrazinocarbonyl)-1H-pyrazole-1-yl]benzenesulfonamide (1583315-62-1)

Guidance literature:

With hydrazine hydrate; In tetrahydrofuran; methanol; Reflux;

DOI:10.1016/j.ejmech.2014.02.023

Reference yield:

4-(3-(4-chlorophenyl)-4-formyl-1H-pyrazol-1-yl)benzenesulfonamide (1135953-03-5) → 4-[3-(4-chlorophenyl)-4-(hydrazinocarbonyl)-1H-pyrazole-1-yl]benzenesulfonamide (1583315-62-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium permanganate / pyridine

2: sulfuric acid / tetrahydrofuran / 48 h / Reflux

3: hydrazine hydrate / tetrahydrofuran; methanol / Reflux

With potassium permanganate; sulfuric acid; hydrazine hydrate; In tetrahydrofuran; pyridine; methanol;

DOI:10.1016/j.ejmech.2014.02.023

Reference yield:

1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid (1293980-87-6) → 4-[3-(4-chlorophenyl)-4-(hydrazinocarbonyl)-1H-pyrazole-1-yl]benzenesulfonamide (1583315-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / tetrahydrofuran / 48 h / Reflux

2: hydrazine hydrate / tetrahydrofuran; methanol / Reflux

With sulfuric acid; hydrazine hydrate; In tetrahydrofuran; methanol;

DOI:10.1016/j.ejmech.2014.02.023

upstream raw materials:

methyl 1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylate

4-(3-(4-chlorophenyl)-4-formyl-1H-pyrazol-1-yl)benzenesulfonamide

1-[4-(aminosulfonyl)phenyl]-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid