1-[(2R,4S,5R)-4-Hydroxy-5-(6-oxo-6,7-dihydro-5H-5,7-diaza-6λ⁵-phospha-dibenzo[a,c]cyclohepten-6-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-[(2R,4S,5R)-4-Hydroxy-5-(6-oxo-6,7-dihydro-5H-5,7-diaza-6λ⁵-phospha-dibenzo[a,c]cyclohepten-6-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
• CAS No.: 90399-73-8
• Molecular Formula: C₂₂H₂₃N₄O₆P
• Molecular Weight: 470.422
• Mol file: 90399-73-8.mol

Synonyms:1-[(2R,4S,5R)-4-Hydroxy-5-(6-oxo-6,7-dihydro-5H-5,7-diaza-6λ⁵-phospha-dibenzo[a,c]cyclohepten-6-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property of 1-[(2R,4S,5R)-4-Hydroxy-5-(6-oxo-6,7-dihydro-5H-5,7-diaza-6λ⁵-phospha-dibenzo[a,c]cyclohepten-6-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(2R,4S,5R)-4-Hydroxy-5-(6-oxo-6,7-dihydro-5H-5,7-diaza-6λ⁵-phospha-dibenzo[a,c]cyclohepten-6-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

There total 3 articles about 1-[(2R,4S,5R)-4-Hydroxy-5-(6-oxo-6,7-dihydro-5H-5,7-diaza-6λ⁵-phospha-dibenzo[a,c]cyclohepten-6-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

thymidine 5'-phosphate (365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1) → 1-[(2R,4S,5R)-4-Hydroxy-5-(6-oxo-6,7-dihydro-5H-5,7-diaza-6λ5-phospha-dibenzo[a,c]cyclohepten-6-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione (90399-73-8)

Guidance literature:

With 2,2'-dipyridyldisulphide; triphenylphosphine; In pyridine; for 3h; Ambient temperature;

DOI:10.1246/cl.1984.175

Reference yield: 74.0%

1,1'-biphenyl-2,2'-diamine (1454-80-4) + thymidine 5'-phosphate (365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1) → 1-[(2R,4S,5R)-4-Hydroxy-5-(6-oxo-6,7-dihydro-5H-5,7-diaza-6λ5-phospha-dibenzo[a,c]cyclohepten-6-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione (90399-73-8)

Guidance literature:

With 2,2'-dipyridyldisulphide; triphenylphosphine; In pyridine; for 3h; Ambient temperature; method for protection of 5'-terminal phosphate of deoxyribo(oligo)nucleotides;

DOI:10.1246/cl.1984.175

Reference yield:

C32H36N6O13P2 (90399-78-3) → thymidine 5'-phosphate (365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1) + 1-[(2R,4S,5R)-4-Hydroxy-5-(6-oxo-6,7-dihydro-5H-5,7-diaza-6λ5-phospha-dibenzo[a,c]cyclohepten-6-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione (90399-73-8)

Guidance literature:

With snake venom phosphodiesterase; In water; for 5.5h; compatibility of enzymic degradation with the 5'-phosphate protection;

DOI:10.1246/cl.1984.175

upstream raw materials:

1,1'-biphenyl-2,2'-diamine

thymidine 5'-phosphate

C₃₂H₃₆N₆O₁₃P₂

Downstream raw materials:

thymidine 5'-phosphate

C₄₀H₄₃N₇O₁₃P₂

C₃₈H₄₁N₇O₁₂P₂