(6S)-tert-butyl-6-phenyl-3-(4-trifluoromethylphenyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate

Base Information

Chemical Name:(6S)-tert-butyl-6-phenyl-3-(4-trifluoromethylphenyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate
CAS No.:1331829-30-1
Molecular Formula:C₂₃H₂₃F₃N₄O₂
Molecular Weight:444.456
Hs Code.:

Synonyms:(6S)-tert-butyl-6-phenyl-3-(4-trifluoromethylphenyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate

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Chemical Property of (6S)-tert-butyl-6-phenyl-3-(4-trifluoromethylphenyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate

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Technology Process of (6S)-tert-butyl-6-phenyl-3-(4-trifluoromethylphenyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate

There total 4 articles about (6S)-tert-butyl-6-phenyl-3-(4-trifluoromethylphenyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 455-13-0
4-Iodobenzotrifluoride

: 1160187-50-7
(S)-tert-butyl-2-azido-1-phenyl-ethyl(prop-2-ynyl)carbamate

: 1331829-30-1
(6S)-tert-butyl-6-phenyl-3-(4-trifluoromethylphenyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate

Guidance literature:: 4-Iodobenzotrifluoride; With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

(S)-tert-butyl-2-azido-1-phenyl-ethyl(prop-2-ynyl)carbamate; With copper(l) iodide; In N,N-dimethyl-formamide; at 20 - 95 ℃; Inert atmosphere;
DOI:10.1039/c1ob05255a

Reference yield:

: 117049-14-6
tert-butyl N-[(1S)-2-hydroxy-1-phenylethyl]carbamate

: 1331829-30-1
(6S)-tert-butyl-6-phenyl-3-(4-trifluoromethylphenyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

2.1: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere; Cooling with ice

3.2: 0.5 h / 0 - 20 °C / Inert atmosphere

4.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

4.2: 20 - 95 °C / Inert atmosphere

With pyridine; sodium azide; tetrabutylammomium bromide; palladium diacetate; sodium hydride; potassium carbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c1ob05255a

Reference yield:

: 110143-62-9
(S)-(+)-<2-<(methylsulfonyl)oxy>-1-phenylethyl>carbamic acid 1,1-dimethylethyl ester

: 1331829-30-1
(6S)-tert-butyl-6-phenyl-3-(4-trifluoromethylphenyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 0.5 h / 0 - 20 °C / Inert atmosphere

3.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

3.2: 20 - 95 °C / Inert atmosphere

With sodium azide; tetrabutylammomium bromide; palladium diacetate; sodium hydride; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c1ob05255a