(6S)-3-(4-trifluoromethylphenyl)-6-phenyl-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine

Base Information

Chemical Name:(6S)-3-(4-trifluoromethylphenyl)-6-phenyl-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine
CAS No.:1331829-36-7
Molecular Formula:C₁₈H₁₅F₃N₄
Molecular Weight:344.339
Hs Code.:

Synonyms:(6S)-3-(4-trifluoromethylphenyl)-6-phenyl-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine

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Chemical Property of (6S)-3-(4-trifluoromethylphenyl)-6-phenyl-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine

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Technology Process of (6S)-3-(4-trifluoromethylphenyl)-6-phenyl-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine

There total 5 articles about (6S)-3-(4-trifluoromethylphenyl)-6-phenyl-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1331829-30-1
(6S)-tert-butyl-6-phenyl-3-(4-trifluoromethylphenyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate

: 1331829-36-7
(6S)-3-(4-trifluoromethylphenyl)-6-phenyl-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c1ob05255a

Reference yield:

: 1160187-50-7
(S)-tert-butyl-2-azido-1-phenyl-ethyl(prop-2-ynyl)carbamate

: 1331829-36-7
(6S)-3-(4-trifluoromethylphenyl)-6-phenyl-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 20 - 95 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1ob05255a

Reference yield:

: 117049-14-6
tert-butyl N-[(1S)-2-hydroxy-1-phenylethyl]carbamate

: 1331829-36-7
(6S)-3-(4-trifluoromethylphenyl)-6-phenyl-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

2.1: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere; Cooling with ice

3.2: 0.5 h / 0 - 20 °C / Inert atmosphere

4.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

4.2: 20 - 95 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; sodium azide; tetrabutylammomium bromide; palladium diacetate; sodium hydride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c1ob05255a