3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(propyloxy)benzenesu Ifonamide

Base Information

Chemical Name:3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(propyloxy)benzenesu Ifonamide
CAS No.:1351089-20-7
Molecular Formula:C₁₅H₁₇BrN₆O₃S
Molecular Weight:441.308
Hs Code.:

Synonyms:3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(propyloxy)benzenesu Ifonamide

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Chemical Property of 3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(propyloxy)benzenesu Ifonamide

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Technology Process of 3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(propyloxy)benzenesu Ifonamide

There total 5 articles about 3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(propyloxy)benzenesu Ifonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.6%

: 71-23-8
propan-1-ol

: 1351094-39-7
3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-4-fluoro-N-methylbenzenesulfonamide

: 1351089-20-7
3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(propyloxy)benzenesu Ifonamide

Guidance literature:: propan-1-ol; With sodium hydride; In mineral oil; at 20 ℃; for 0.5h;

3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-4-fluoro-N-methylbenzenesulfonamide; In mineral oil; at 20 - 100 ℃; for 72.5h;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1351089-20-7
3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(propyloxy)benzenesu Ifonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorosulfonic acid / 18 h / 100 °C

2.1: triethylamine / tetrahydrofuran / 1 h / -35 °C

3.1: hydrogen / palladium / tetrahydrofuran / 50 °C / Inert atmosphere

4.1: acetic acid / 1,4-dioxane / 18 h / 100 °C / Sealed tube

5.1: sodium hydride / mineral oil / 0.5 h / 20 °C

5.2: 72.5 h / 20 - 100 °C

With chlorosulfonic acid; hydrogen; sodium hydride; acetic acid; triethylamine; palladium; In tetrahydrofuran; 1,4-dioxane; mineral oil;

Reference yield:

: 6668-56-0
4-fluoro-3-nitrobenzene-1-sulfonyl chloride

: 1351089-20-7
3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(propyloxy)benzenesu Ifonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 1 h / -35 °C

2.1: hydrogen / palladium / tetrahydrofuran / 50 °C / Inert atmosphere

3.1: acetic acid / 1,4-dioxane / 18 h / 100 °C / Sealed tube

4.1: sodium hydride / mineral oil / 0.5 h / 20 °C

4.2: 72.5 h / 20 - 100 °C

With hydrogen; sodium hydride; acetic acid; triethylamine; palladium; In tetrahydrofuran; 1,4-dioxane; mineral oil;