ethyl 5-(4-methoxyphenyl)-2-methyl-4,5-dihydrofuran-3-carboxylate

Base Information

• Chemical Name: ethyl 5-(4-methoxyphenyl)-2-methyl-4,5-dihydrofuran-3-carboxylate
• CAS No.: 74947-72-1
• Molecular Formula: C₁₅H₁₈O₄
• Molecular Weight: 262.306
• Mol file: 74947-72-1.mol

Synonyms:ethyl 5-(4-methoxyphenyl)-2-methyl-4,5-dihydrofuran-3-carboxylate

Chemical Property of ethyl 5-(4-methoxyphenyl)-2-methyl-4,5-dihydrofuran-3-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 5-(4-methoxyphenyl)-2-methyl-4,5-dihydrofuran-3-carboxylate

There total 3 articles about ethyl 5-(4-methoxyphenyl)-2-methyl-4,5-dihydrofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethyl 1-acetyl-2-(4-methoxyphenyl)cyclopropane-1-carboxylate → ethyl 5-(4-methoxyphenyl)-2-methyl-4,5-dihydrofuran-3-carboxylate (74947-72-1)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In dimethyl sulfoxide; at 120 ℃; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.7b00805

Reference yield: 68.0%

4-Methoxystyrene (637-69-4,24936-44-5) + ethyl acetoacetate (141-97-9) → ethyl 5-(4-methoxyphenyl)-2-methyl-4,5-dihydrofuran-3-carboxylate (74947-72-1)

Guidance literature:

With di-tert-butyl peroxide; copper dichloride; In acetonitrile; at 80 ℃; for 28h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201503822

Reference yield:

4-Methoxystyrene (637-69-4,24936-44-5) + ethyl 2-diazo-3-oxobutanoate (2009-97-4) → ethyl 5-(4-methoxyphenyl)-2-methyl-4,5-dihydrofuran-3-carboxylate (74947-72-1)

Guidance literature:

With aluminum oxide; copper(II) hexafluoro-2,4-pentanedionate; Yield given. Multistep reaction; 1)Thermolysis, 2) 24 h.;

DOI:10.1021/jo01310a062

upstream raw materials:

4-Methoxystyrene

ethyl 2-diazo-3-oxobutanoate

ethyl acetoacetate