1,10-dibromo-5-(O-diethylstilbestryl-[O-tertbutyldimethylsilyl] phenoxymethyl)-2,8-decadiyne

Base Information

Chemical Name:1,10-dibromo-5-(O-diethylstilbestryl-[O-tertbutyldimethylsilyl] phenoxymethyl)-2,8-decadiyne
CAS No.:346700-29-6
Molecular Formula:C₃₅H₄₆Br₂O₂Si
Molecular Weight:686.643
Hs Code.:

Synonyms:1,10-dibromo-5-(O-diethylstilbestryl-[O-tertbutyldimethylsilyl] phenoxymethyl)-2,8-decadiyne

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Chemical Property of 1,10-dibromo-5-(O-diethylstilbestryl-[O-tertbutyldimethylsilyl] phenoxymethyl)-2,8-decadiyne

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Technology Process of 1,10-dibromo-5-(O-diethylstilbestryl-[O-tertbutyldimethylsilyl] phenoxymethyl)-2,8-decadiyne

There total 6 articles about 1,10-dibromo-5-(O-diethylstilbestryl-[O-tertbutyldimethylsilyl] phenoxymethyl)-2,8-decadiyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 346700-35-4
4-((E)-2-{4-[7-Bromo-2-(4-bromo-but-2-ynyl)-hept-5-ynyloxy]-phenyl}-1-ethyl-but-1-enyl)-phenol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 346700-29-6
1,10-dibromo-5-(O-diethylstilbestryl-[O-tertbutyldimethylsilyl] phenoxymethyl)-2,8-decadiyne

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1021/jo0055842

Reference yield:

: 346700-32-1
5-(O-diethylstilbestrol phenoxymethyl)-2,8-decadiyne-1,10-diol

: 346700-29-6
1,10-dibromo-5-(O-diethylstilbestryl-[O-tertbutyldimethylsilyl] phenoxymethyl)-2,8-decadiyne

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / PPh₃; Br₂; 2,6-lutidine / CH₂Cl₂

2: 99 percent / imidazole / dimethylformamide

With 1H-imidazole; 2,6-dimethylpyridine; bromine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0055842

Reference yield:

: 263720-92-9
1,10-dihydroxy-5-tert-butyldimethylsiloxymethyl-2,8-decadiyne

: 346700-29-6
1,10-dibromo-5-(O-diethylstilbestryl-[O-tertbutyldimethylsilyl] phenoxymethyl)-2,8-decadiyne

Guidance literature:: Multi-step reaction with 6 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 0 - 25 °C

2: 56.6 g / TBAF / tetrahydrofuran / 9 h

3: PPh₃; DEAD / tetrahydrofuran / 25 °C

4: TsOH / methanol

5: 80 percent / PPh₃; Br₂; 2,6-lutidine / CH₂Cl₂

6: 99 percent / imidazole / dimethylformamide

With 1H-imidazole; 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; bromine; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0055842