1-PYRAZIN-2-YL-PROPAN-2-ONE

Base Information

• Chemical Name: 1-PYRAZIN-2-YL-PROPAN-2-ONE
• CAS No.: 6784-62-9
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.15
• Hs Code.: 2933990090
• Mol file: 6784-62-9.mol

Synonyms:acetonyl pyrazine;Pyrazine,acetonyl;1-PYRAZIN-2-YL-PROPAN-2-ONE;pyrazinyl-acetone;(2-pyrazinyl)acetone;Pyrazinyl-aceton;1-pyrazin-2-ylacetone;2-acetonyl-pyrazine;1-(2-pyrazinyl)-2-propanone;Acetonylprazine;

Chemical Property of 1-PYRAZIN-2-YL-PROPAN-2-ONE

Chemical Property:

• Vapor Pressure: 0.0947mmHg at 25°C
• Boiling Point: 223.7°C at 760 mmHg
• Flash Point: 91.6°C
• PSA: 42.85000
• Density: 1.113g/cm³
• LogP: 0.60810

Purity/Quality:

97% ^*data from raw suppliers

1-Pyrazin-2-ylacetone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-PYRAZIN-2-YL-PROPAN-2-ONE

There total 3 articles about 1-PYRAZIN-2-YL-PROPAN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-chloropyrazin (14508-49-7) + potassium enolate of acetone (128190-66-9,25088-58-8) → 1-(pyrazin-2-yl)propan-2-one (6784-62-9)

Guidance literature:

In diethyl ether; ammonia; for 0.25h; Mechanism; Product distribution; effect of inhibitor (di-tert-butyl-nitroxide);

DOI:10.1021/jo00315a013

Reference yield:

2-Methylpyrazine (109-08-0) → 1-(pyrazin-2-yl)propan-2-one (6784-62-9)

Guidance literature:

With ammonia; sodium; anschliessend Behandeln mit Aethylacetat in Aether;

DOI:10.1021/ja01528a034

Reference yield:

2-chloropyrazin (14508-49-7) + acetone (67-64-1) → 1-(pyrazin-2-yl)propan-2-one (6784-62-9)

Guidance literature:

With potassium amide; Yield given. Multistep reaction; 1)liqid ammonia, ether; 2) 15 min;

DOI:10.1021/jo00315a013

upstream raw materials:

2-Methylpyrazine

2-chloropyrazin

potassium enolate of acetone

acetone

Downstream raw materials:

(3t-methyl-2r-phenyl-morpholin-4-yl)-(1-methyl-2-pyrazin-2-yl-ethyl)-amine

(phenyl-3 pyrazinyl-2)-1 propanone

methacylidene-2 phenyl-3 benzoyl-4 tetrahydro 1,2,3,4 pyrazine

methacylidene-2 phenyl-3 benzoyl-6 tetrahydro 1,2,3,4 pyrazine

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