(S)-2-(4-methoxybenzyl)oxy-4-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}butyraldehyde

Base Information

Chemical Name:(S)-2-(4-methoxybenzyl)oxy-4-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}butyraldehyde
CAS No.:389086-07-1
Molecular Formula:C₂₆H₄₄O₄S₂Si
Molecular Weight:512.85
Hs Code.:

Synonyms:(S)-2-(4-methoxybenzyl)oxy-4-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}butyraldehyde

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Chemical Property of (S)-2-(4-methoxybenzyl)oxy-4-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}butyraldehyde

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Technology Process of (S)-2-(4-methoxybenzyl)oxy-4-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}butyraldehyde

There total 8 articles about (S)-2-(4-methoxybenzyl)oxy-4-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}butyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 389086-06-0
(S)-2-(4-methoxybenzyl)oxy-4-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}-1-butanol

: 389086-07-1
(S)-2-(4-methoxybenzyl)oxy-4-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}butyraldehyde

Guidance literature:: With pyridine-SO₃ complex; dimethyl sulfoxide; triethylamine; for 1h;
DOI:10.1021/ol0168364

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 389086-07-1
(S)-2-(4-methoxybenzyl)oxy-4-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}butyraldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 6 h / 20 °C

2: 98 percent / imidazole / CH₂Cl₂ / 2 h / 0 - 20 °C

3: 87 percent / diisobutylaluminium hydride / CH₂Cl₂; hexane / 2 h / -78 - -20 °C

4: 92 percent / pyridine*SO₃; Et₃N / dimethylsulfoxide / 1.25 h / 20 °C

With 1H-imidazole; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triethylamine; In hexane; dichloromethane; dimethyl sulfoxide; 4: Parikh-Doering oxidation;
DOI:10.1016/S0040-4020(02)01379-0

Reference yield:

: 389086-04-8
(S)-4-[2-(4-hydroxybutyl)-1,3-dithian-2-yl]-butane-1,2-diol

: 389086-07-1
(S)-2-(4-methoxybenzyl)oxy-4-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}butyraldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 6 h / 20 °C

2: 98 percent / imidazole / CH₂Cl₂ / 2 h / 0 - 20 °C

3: 87 percent / diisobutylaluminium hydride / CH₂Cl₂; hexane / 2 h / -78 - -20 °C

4: 92 percent / pyridine*SO₃; Et₃N / dimethylsulfoxide / 1.25 h / 20 °C

With 1H-imidazole; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triethylamine; In hexane; dichloromethane; dimethyl sulfoxide; 4: Parikh-Doering oxidation;
DOI:10.1016/S0040-4020(02)01379-0