(S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide

Base Information

Chemical Name:(S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide
CAS No.:1043453-94-6
Molecular Formula:C₂₃H₂₉F₂NO₃
Molecular Weight:405.485
Hs Code.:

Synonyms:(S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide

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Technology Process of (S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide

There total 7 articles about (S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1043453-93-5
(R)-3-((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)hexanoyl)-4-benzyloxazolidin-2-one

: 1043453-94-6
(S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide

Guidance literature:: With hydroxylamine; potassium cyanide; In tetrahydrofuran; methanol; water; at 20 ℃;

Reference yield:

: 502-44-3,24980-41-4,80137-66-2
hexahydro-2H-oxepin-2-one

: 1043453-94-6
(S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / toluene / Reflux

2: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

3: hydroxylamine monohydrate / tetrahydrofuran; methanol / 20 °C

With hydroxylamine monohydrate; potassium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/j.bmcl.2011.02.010

Reference yield:

: 261951-70-6
4-(bromomethyl)-1-fluoro-2-methylbenzene

: 1043453-94-6
(S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / toluene / Reflux

2: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

3: hydroxylamine monohydrate / tetrahydrofuran; methanol / 20 °C

With hydroxylamine monohydrate; potassium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/j.bmcl.2011.02.010