(S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide

Base Information

• Chemical Name: (S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide
• CAS No.: 1043453-94-6
• Molecular Formula: C₂₃H₂₉F₂NO₃
• Molecular Weight: 405.485
• Mol file: 1043453-94-6.mol

Synonyms:(S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide

Chemical Property of (S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide

There total 7 articles about (S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

(R)-3-((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)hexanoyl)-4-benzyloxazolidin-2-one (1043453-93-5) → (S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide (1043453-94-6)

Guidance literature:

With hydroxylamine; potassium cyanide; In tetrahydrofuran; methanol; water; at 20 ℃;

Reference yield:

hexahydro-2H-oxepin-2-one (502-44-3,24980-41-4,80137-66-2) → (S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide (1043453-94-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / toluene / Reflux

2: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

3: hydroxylamine monohydrate / tetrahydrofuran; methanol / 20 °C

With hydroxylamine monohydrate; potassium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene;

DOI:10.1016/j.bmcl.2011.02.010

Reference yield:

4-(bromomethyl)-1-fluoro-2-methylbenzene (261951-70-6) → (S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide (1043453-94-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / toluene / Reflux

2: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

3: hydroxylamine monohydrate / tetrahydrofuran; methanol / 20 °C

With hydroxylamine monohydrate; potassium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene;

DOI:10.1016/j.bmcl.2011.02.010

upstream raw materials:

(R)-3-((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)hexanoyl)-4-benzyloxazolidin-2-one

hexahydro-2H-oxepin-2-one

5-(bromomethyl)-2-fluoro-1,3-dimethylbenzene

6-(4-fluoro-3-methylbenzyloxy)hexanoic acid