tert-butyl [(4R)-15-cyclohexyl-12-(cyclopropylcarbamoyl)-5,6,8,9-tetrahydro-4H-indolo[1',2':4,5][1,4]diazepino[6,7,1-ij]quinolin-4-yl]carbamate

Base Information

• Chemical Name: tert-butyl [(4R)-15-cyclohexyl-12-(cyclopropylcarbamoyl)-5,6,8,9-tetrahydro-4H-indolo[1',2':4,5][1,4]diazepino[6,7,1-ij]quinolin-4-yl]carbamate
• CAS No.: 1169857-13-9
• Molecular Formula: C₃₄H₄₂N₄O₃
• Molecular Weight: 554.732

Synonyms:tert-butyl [(4R)-15-cyclohexyl-12-(cyclopropylcarbamoyl)-5,6,8,9-tetrahydro-4H-indolo[1',2':4,5][1,4]diazepino[6,7,1-ij]quinolin-4-yl]carbamate

Chemical Property of tert-butyl [(4R)-15-cyclohexyl-12-(cyclopropylcarbamoyl)-5,6,8,9-tetrahydro-4H-indolo[1',2':4,5][1,4]diazepino[6,7,1-ij]quinolin-4-yl]carbamate

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Technology Process of tert-butyl [(4R)-15-cyclohexyl-12-(cyclopropylcarbamoyl)-5,6,8,9-tetrahydro-4H-indolo[1',2':4,5][1,4]diazepino[6,7,1-ij]quinolin-4-yl]carbamate

There total 1 articles about tert-butyl [(4R)-15-cyclohexyl-12-(cyclopropylcarbamoyl)-5,6,8,9-tetrahydro-4H-indolo[1',2':4,5][1,4]diazepino[6,7,1-ij]quinolin-4-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4R)-4-[(tert-butoxycarbonyl)amino]-15-cyclohexyl-5,6,8,9-tetrahydro-4H-indolo[1',2':4,5][1,4]diazepino[6,7,1-ij]quinoline-12-carboxylic acid (1169856-97-6) + Cyclopropylamine (765-30-0) → tert-butyl [(4R)-15-cyclohexyl-12-(cyclopropylcarbamoyl)-5,6,8,9-tetrahydro-4H-indolo[1',2':4,5][1,4]diazepino[6,7,1-ij]quinolin-4-yl]carbamate (1169857-13-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 - 20 ℃;

Reference yield:

tert-butyl [(4R)-15-cyclohexyl-12-(cyclopropylcarbamoyl)-5,6,8,9-tetrahydro-4H-indolo[1',2':4,5][1,4]diazepino[6,7,1-ij]quinolin-4-yl]carbamate (1169857-13-9) → (4R)-4-amino-15-cyclohexyl-N-cyclopropyl-5,6,8,9-tetrahydro-4H-indolo[1',2':4,5][1,4]diazepino[6,7,1-ij]quinoline-12-carboxamide (1169854-48-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃;

upstream raw materials:

(4R)-4-[(tert-butoxycarbonyl)amino]-15-cyclohexyl-5,6,8,9-tetrahydro-4H-indolo[1',2':4,5][1,4]diazepino[6,7,1-ij]quinoline-12-carboxylic acid

Cyclopropylamine

Downstream raw materials:

(4R)-4-amino-15-cyclohexyl-N-cyclopropyl-5,6,8,9-tetrahydro-4H-indolo[1',2':4,5][1,4]diazepino[6,7,1-ij]quinoline-12-carboxamide

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