N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidin-2-yl}glycine

Base Information

Chemical Name:N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidin-2-yl}glycine
CAS No.:1234620-06-4
Molecular Formula:C₂₃H₁₆F₃N₇O₂
Molecular Weight:479.421
Hs Code.:

Synonyms:N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidin-2-yl}glycine

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Chemical Property of N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidin-2-yl}glycine

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Technology Process of N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidin-2-yl}glycine

There total 4 articles about N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidin-2-yl}glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1234620-04-2
tert-Butyl N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro [1,2,4]triazolo[1,5-a]pyrimidin-2-yl}glycinate

: 1234620-06-4
N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidin-2-yl}glycine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.25h; Inert atmosphere;

Reference yield:

: 1234619-70-5
benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

: 1234620-06-4
N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidin-2-yl}glycine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 0.5 h / 20 °C / 760.05 Torr

3: trifluoroacetic acid / dichloromethane / 1.25 h / 20 °C / Inert atmosphere

With hydrogen; potassium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1234737-79-1
(7R)-2-amino-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

: 1234620-06-4
N-{(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidin-2-yl}glycine

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 12 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 0.5 h / 20 °C / 760.05 Torr

4: trifluoroacetic acid / dichloromethane / 1.25 h / 20 °C / Inert atmosphere

With pyridine; hydrogen; potassium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;