1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(S)-(γ-chlorosulfonamido)pyrrolidine

Base Information

Chemical Name:1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(S)-(γ-chlorosulfonamido)pyrrolidine
CAS No.:1055034-49-5
Molecular Formula:C₁₄H₂₅ClN₂O₆S
Molecular Weight:384.881
Hs Code.:

Synonyms:1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(S)-(γ-chlorosulfonamido)pyrrolidine

Suppliers and Price of 1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(S)-(γ-chlorosulfonamido)pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(S)-(γ-chlorosulfonamido)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(S)-(γ-chlorosulfonamido)pyrrolidine

There total 1 articles about 1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(S)-(γ-chlorosulfonamido)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1633-82-5
3-chloro-n-propanesulfonyl chloride

: 254881-77-1,1018667-18-9
1-tert-butyl 2-methyl (2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate

: 1055034-49-5
1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(S)-(γ-chlorosulfonamido)pyrrolidine

Guidance literature:: With triethylamine; In dichloromethane; for 18h;
DOI:10.1021/jm000246e

Reference yield:

: 1055034-49-5
1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(S)-(γ-chlorosulfonamido)pyrrolidine

: 317860-19-8
1N-(4-n-propoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-(γ-sultam-1N-yl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / DBU / dimethylformamide / 18 h

2: TFA / CH₂Cl₂ / 2 h

3: Et₃N / dioxane; H₂O / 16 h

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000246e

Reference yield:

: 1055034-49-5
1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(S)-(γ-chlorosulfonamido)pyrrolidine

: (2R,4S)-4-(1,1-Dioxo-1λ⁶-isothiazolidin-2-yl)-1-(4-propoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid hydroxyamide

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / DBU / dimethylformamide / 18 h

2: TFA / CH₂Cl₂ / 2 h

3: Et₃N / dioxane; H₂O / 16 h

4: NH₂OK / methanol

With hydroxylamine potassium salt; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000246e