(+)-(2S)-Methyl 3-amino-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>propanoate

Base Information

Chemical Name:(+)-(2S)-Methyl 3-amino-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>propanoate
CAS No.:151074-93-0
Molecular Formula:C₁₄H₁₈N₂O₄
Molecular Weight:278.308
Hs Code.:

Synonyms:(+)-(2S)-Methyl 3-amino-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>propanoate

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Chemical Property of (+)-(2S)-Methyl 3-amino-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>propanoate

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Technology Process of (+)-(2S)-Methyl 3-amino-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>propanoate

There total 8 articles about (+)-(2S)-Methyl 3-amino-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 151074-92-9
(+)-(2S)-Methyl 3-(benzylamino)-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>propanoate

: 151074-93-0
(+)-(2S)-Methyl 3-amino-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>propanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; for 16h; under 2068.6 Torr;
DOI:10.1021/jo00074a016

Reference yield:

: 134627-50-2
(6S,7S)-7-<(4S)-2-Oxo-4-phenyl-1,3-oxazolidin-3-yl>-1-aza-5-oxabicyclo<4.2.0>octan-8-one

: 151074-93-0
(+)-(2S)-Methyl 3-amino-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / KHMDS / toluene; tetrahydrofuran; dimethylformamide / 1.) -78 deg C, 1 h, 2.) -78 deg C, 15 min

2: HCl / methanol / 24 h / 25 °C

3: 50 percent / 1 N HCl / tetrahydrofuran / 48 h / 25 °C

4: NaBH(OAc)3 / tetrahydrofuran / 16 h / 25 °C

5: NaBH₄ / methanol / 0.5 h / 0 °C

6: 95 percent / H₂ / 10percent Pd/C / methanol / 16 h / 25 °C / 2068.6 Torr

With hydrogenchloride; sodium tetrahydroborate; hydrogen; potassium hexamethylsilazane; sodium tris(acetoxy)borohydride; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00074a016

Reference yield:

: (S)-3-[(E)-Benzylimino]-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propionic acid methyl ester

: 151074-93-0
(+)-(2S)-Methyl 3-amino-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄ / methanol / 0.5 h / 0 °C

2: 95 percent / H₂ / 10percent Pd/C / methanol / 16 h / 25 °C / 2068.6 Torr

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1021/jo00074a016