(3(2S),4R)-4-(diphenylmethyl)-3-[bis-(3',4'-methylenedioxyphenyl)-methyl]-(4-oxo-butyric acid tert-butyl ester)-2-oxazolidinone

Base Information

Chemical Name:(3(2S),4R)-4-(diphenylmethyl)-3-[bis-(3',4'-methylenedioxyphenyl)-methyl]-(4-oxo-butyric acid tert-butyl ester)-2-oxazolidinone
CAS No.:404953-28-2
Molecular Formula:C₃₉H₃₇NO₉
Molecular Weight:663.724
Hs Code.:

Synonyms:(3(2S),4R)-4-(diphenylmethyl)-3-[bis-(3',4'-methylenedioxyphenyl)-methyl]-(4-oxo-butyric acid tert-butyl ester)-2-oxazolidinone

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Chemical Property of (3(2S),4R)-4-(diphenylmethyl)-3-[bis-(3',4'-methylenedioxyphenyl)-methyl]-(4-oxo-butyric acid tert-butyl ester)-2-oxazolidinone

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Technology Process of (3(2S),4R)-4-(diphenylmethyl)-3-[bis-(3',4'-methylenedioxyphenyl)-methyl]-(4-oxo-butyric acid tert-butyl ester)-2-oxazolidinone

There total 5 articles about (3(2S),4R)-4-(diphenylmethyl)-3-[bis-(3',4'-methylenedioxyphenyl)-methyl]-(4-oxo-butyric acid tert-butyl ester)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 49827-15-8
t-butyl iodoacetate

: 404953-21-5
(4R)-4-(diphenylmethyl)-3-[3-(3,3-bis-3',4'-methylenedioxyphenyl)-propanoyl]-2-oxazolidinone

: 404953-28-2
(3(2S),4R)-4-(diphenylmethyl)-3-[bis-(3',4'-methylenedioxyphenyl)-methyl]-(4-oxo-butyric acid tert-butyl ester)-2-oxazolidinone

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 6h;
DOI:10.1139/cjc-79-11-1546

Reference yield:

: 2635-13-4
1,2-(methylenedioxy)-4-bromobenzene

: 404953-28-2
(3(2S),4R)-4-(diphenylmethyl)-3-[bis-(3',4'-methylenedioxyphenyl)-methyl]-(4-oxo-butyric acid tert-butyl ester)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg / tetrahydrofuran / 0.33 h

1.2: 89 percent / CuBr*Me₂S / tetrahydrofuran / -48 - 4.5 °C

2.1: 74 percent / sodium hexamethyldisilazide / tetrahydrofuran / 6 h / -78 °C

With sodium hexamethyldisilazane; magnesium; In tetrahydrofuran; 1.2: Grignard reaction;
DOI:10.1139/cjc-79-11-1546

Reference yield:

: 96249-87-5,26930-49-4
3-benzo[1,3]dioxol-5-yl-acryloyl chloride

: 404953-28-2
(3(2S),4R)-4-(diphenylmethyl)-3-[bis-(3',4'-methylenedioxyphenyl)-methyl]-(4-oxo-butyric acid tert-butyl ester)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / n-BuLi / tetrahydrofuran / 3 h / -78 °C

2.1: Mg / tetrahydrofuran / 0.33 h

2.2: 89 percent / CuBr*Me₂S / tetrahydrofuran / -48 - 4.5 °C

3.1: 74 percent / sodium hexamethyldisilazide / tetrahydrofuran / 6 h / -78 °C

With n-butyllithium; sodium hexamethyldisilazane; magnesium; In tetrahydrofuran; 2.2: Grignard reaction;
DOI:10.1139/cjc-79-11-1546