(2S,3R,6S)-10-Acetyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide

Base Information

Chemical Name:(2S,3R,6S)-10-Acetyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide
CAS No.:191408-34-1
Molecular Formula:C₃₂H₄₄N₄O₆
Molecular Weight:580.725
Hs Code.:

Synonyms:(2S,3R,6S)-10-Acetyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide

Suppliers and Price of (2S,3R,6S)-10-Acetyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R,6S)-10-Acetyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R,6S)-10-Acetyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide

There total 14 articles about (2S,3R,6S)-10-Acetyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82859-39-0
trans-cinnamyl iodide

: 191408-34-1
(2S,3R,6S)-10-Acetyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide

Guidance literature:: Multi-step reaction with 12 steps

1: 1.) LDA, 2.) TMEDA / 1.) THF, from -45 to -20 deg C, 1.5 h, 2.) THF, from -45 to -20 deg C, 3 h

2: aq. NaOH / methanol

3: BOP, i-Pr₂NEt / dimethylformamide

4: 74 percent / NaH / dimethylformamide / 0 °C

5: 80 percent / HCl / dioxane

6: 1.) i-Pr₂NEt / 1.) acetonitrile, 2.) acetonitrile

7: H₂ / Pd/C / methanol

8: H₂ / Pd(OH)2/C

9: NaIO₄, aq. RuCl₃ / acetonitrile; CCl₄

10: BOP-Cl, NMM / tetrahydrofuran

11: HCl / dioxane

12: i-Pr₂NEt / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; ruthenium trichloride; sodium hydroxide; sodium periodate; N,N,N,N,-tetramethylethylenediamine; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(99)00215-2

Reference yield:

: 178932-85-9
N-δ-tert-butoxycarbonyl-L-ornithine methyl amide

: 191408-34-1
(2S,3R,6S)-10-Acetyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide

Guidance literature:: Multi-step reaction with 10 steps

1: BOP, i-Pr₂NEt / dimethylformamide

2: 74 percent / NaH / dimethylformamide / 0 °C

3: 80 percent / HCl / dioxane

4: 1.) i-Pr₂NEt / 1.) acetonitrile, 2.) acetonitrile

5: H₂ / Pd/C / methanol

6: H₂ / Pd(OH)2/C

7: NaIO₄, aq. RuCl₃ / acetonitrile; CCl₄

8: BOP-Cl, NMM / tetrahydrofuran

9: HCl / dioxane

10: i-Pr₂NEt / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; ruthenium trichloride; sodium periodate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(99)00215-2

Reference yield:

: 4392-24-9
Cinnamyl bromide

: 191408-34-1
(2S,3R,6S)-10-Acetyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide

Guidance literature:: Multi-step reaction with 12 steps

1: 1.) LDA, 2.) TMEDA / 1.) THF, from -45 to -20 deg C, 1.5 h, 2.) THF, from -45 to -20 deg C, 3 h

2: aq. NaOH / methanol

3: BOP, i-Pr₂NEt / dimethylformamide

4: 74 percent / NaH / dimethylformamide / 0 °C

5: 80 percent / HCl / dioxane

6: 1.) i-Pr₂NEt / 1.) acetonitrile, 2.) acetonitrile

7: H₂ / Pd/C / methanol

8: H₂ / Pd(OH)2/C

9: NaIO₄, aq. RuCl₃ / acetonitrile; CCl₄

10: BOP-Cl, NMM / tetrahydrofuran

11: HCl / dioxane

12: i-Pr₂NEt / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; ruthenium trichloride; sodium hydroxide; sodium periodate; N,N,N,N,-tetramethylethylenediamine; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(99)00215-2