(2S,3R,6S)-4-Oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide

Base Information

• Chemical Name: (2S,3R,6S)-4-Oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide
• CAS No.: 791043-26-0
• Molecular Formula: C₃₀H₄₂N₄O₅
• Molecular Weight: 538.687

Synonyms:

Chemical Property of (2S,3R,6S)-4-Oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R,6S)-4-Oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide

There total 13 articles about (2S,3R,6S)-4-Oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-cinnamyl iodide (82859-39-0) → (2S,3R,6S)-4-Oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide (791043-26-0)

Guidance literature:

Multi-step reaction with 11 steps

1: 1.) LDA, 2.) TMEDA / 1.) THF, from -45 to -20 deg C, 1.5 h, 2.) THF, from -45 to -20 deg C, 3 h

2: aq. NaOH / methanol

3: BOP, i-Pr₂NEt / dimethylformamide

4: 74 percent / NaH / dimethylformamide / 0 °C

5: 80 percent / HCl / dioxane

6: 1.) i-Pr₂NEt / 1.) acetonitrile, 2.) acetonitrile

7: H₂ / Pd/C / methanol

8: H₂ / Pd(OH)2/C

9: NaIO₄, aq. RuCl₃ / acetonitrile; CCl₄

10: BOP-Cl, NMM / tetrahydrofuran

11: HCl / dioxane

With 4-methyl-morpholine; hydrogenchloride; ruthenium trichloride; sodium hydroxide; sodium periodate; N,N,N,N,-tetramethylethylenediamine; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(99)00215-2

Reference yield:

N-δ-tert-butoxycarbonyl-L-ornithine methyl amide (178932-85-9) → (2S,3R,6S)-4-Oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide (791043-26-0)

Guidance literature:

Multi-step reaction with 9 steps

1: BOP, i-Pr₂NEt / dimethylformamide

2: 74 percent / NaH / dimethylformamide / 0 °C

3: 80 percent / HCl / dioxane

4: 1.) i-Pr₂NEt / 1.) acetonitrile, 2.) acetonitrile

5: H₂ / Pd/C / methanol

6: H₂ / Pd(OH)2/C

7: NaIO₄, aq. RuCl₃ / acetonitrile; CCl₄

8: BOP-Cl, NMM / tetrahydrofuran

9: HCl / dioxane

With 4-methyl-morpholine; hydrogenchloride; ruthenium trichloride; sodium periodate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(99)00215-2

Reference yield:

Cinnamyl bromide (4392-24-9) → (2S,3R,6S)-4-Oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide (791043-26-0)

Guidance literature:

Multi-step reaction with 11 steps

1: 1.) LDA, 2.) TMEDA / 1.) THF, from -45 to -20 deg C, 1.5 h, 2.) THF, from -45 to -20 deg C, 3 h

2: aq. NaOH / methanol

3: BOP, i-Pr₂NEt / dimethylformamide

4: 74 percent / NaH / dimethylformamide / 0 °C

5: 80 percent / HCl / dioxane

6: 1.) i-Pr₂NEt / 1.) acetonitrile, 2.) acetonitrile

7: H₂ / Pd/C / methanol

8: H₂ / Pd(OH)2/C

9: NaIO₄, aq. RuCl₃ / acetonitrile; CCl₄

10: BOP-Cl, NMM / tetrahydrofuran

11: HCl / dioxane

With 4-methyl-morpholine; hydrogenchloride; ruthenium trichloride; sodium hydroxide; sodium periodate; N,N,N,N,-tetramethylethylenediamine; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(99)00215-2

upstream raw materials:

(2S,3R,6S)-2-Benzyloxycarbamoyl-6-methylcarbamoyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-10-carboxylic acid tert-butyl ester

trans-cinnamyl iodide

N-δ-tert-butoxycarbonyl-L-ornithine methyl amide

Cinnamyl bromide

Downstream raw materials:

(2S,3R,6S)-10-Acetyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 791043-26-0 (2S,3R,6S)-4-Oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send