Technology Process of N-allyl-N'-methyl-3α-(3,5-dichlorobenzoyl)amino-12α-hydroxy-5β-cholan-24-amide
There total 7 articles about N-allyl-N'-methyl-3α-(3,5-dichlorobenzoyl)amino-12α-hydroxy-5β-cholan-24-amide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3α-N-(3,5-dichlorobenzoyl)amino-12α-hydroxy-5β-cholan-24-oic acid;
With
tributyl-amine; chloroformic acid ethyl ester;
In
1,4-dioxane;
at 10 ℃;
for 0.166667h;
N-methyl-N-allylamine;
In
1,4-dioxane;
at 10 - 20 ℃;
for 3h;
DOI:10.1016/S0957-4166(01)00490-6
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: HCl
2.1: PPh3; DEAD / tetrahydrofuran / 24 h / 40 °C
3.1: 5.8 g / NaN3 / dimethylformamide / 48 h / 40 °C
4.1: 5.25 g / H2 / Pd/C / ethyl acetate; methanol / 24 h / 20 °C / 6460 Torr
5.1: 3.30 g / Et3N / tetrahydrofuran / 4 h / 20 °C
6.1: 94 percent / aq. LiOH / tetrahydrofuran; methanol / 5 h / 20 °C
7.1: tri-n-butyl amine; ethyl chloroformate / dioxane / 0.17 h / 10 °C
7.2: 50 percent / dioxane / 3 h / 10 - 20 °C
With
hydrogenchloride; lithium hydroxide; sodium azide; tributyl-amine; hydrogen; chloroformic acid ethyl ester; triethylamine; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(01)00490-6
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: PPh3; DEAD / tetrahydrofuran / 24 h / 40 °C
2.1: 5.8 g / NaN3 / dimethylformamide / 48 h / 40 °C
3.1: 5.25 g / H2 / Pd/C / ethyl acetate; methanol / 24 h / 20 °C / 6460 Torr
4.1: 3.30 g / Et3N / tetrahydrofuran / 4 h / 20 °C
5.1: 94 percent / aq. LiOH / tetrahydrofuran; methanol / 5 h / 20 °C
6.1: tri-n-butyl amine; ethyl chloroformate / dioxane / 0.17 h / 10 °C
6.2: 50 percent / dioxane / 3 h / 10 - 20 °C
With
lithium hydroxide; sodium azide; tributyl-amine; hydrogen; chloroformic acid ethyl ester; triethylamine; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(01)00490-6
