5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(4-chlorobenzyl) phosphotriester

Base Information

Chemical Name:5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(4-chlorobenzyl) phosphotriester
CAS No.:173606-88-7
Molecular Formula:C₂₇H₃₀ClN₁₀O₁₀P
Molecular Weight:721.023
Hs Code.:

Synonyms:5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(4-chlorobenzyl) phosphotriester

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Chemical Property of 5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(4-chlorobenzyl) phosphotriester

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Technology Process of 5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(4-chlorobenzyl) phosphotriester

There total 4 articles about 5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(4-chlorobenzyl) phosphotriester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

: 173606-88-7
5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(4-chlorobenzyl) phosphotriester

Guidance literature:: Multi-step reaction with 5 steps

1: DIPEA / acetonitrile / 0.25 h / 0 °C

2: 1.) 1H-tetrazole, 2.) H₂O / 1.) CH₃CN, 0 deg C, 30 min, 2.) 25 deg C, 45 min

3: I₂, H₂O, pyridine / 0.25 h / 25 °C

5: 50 percent / acetonitrile / 1.) r.t., 80 min, 2.) 85 deg C, 30 min

With pyridine; 1H-tetrazole; water; iodine; N-ethyl-N,N-diisopropylamine; In acetonitrile;

Reference yield:

: 151029-28-6
5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl) H-phosphonate diester

: 173606-88-7
5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(4-chlorobenzyl) phosphotriester

Guidance literature:: Multi-step reaction with 3 steps

1: I₂, H₂O, pyridine / 0.25 h / 25 °C

3: 50 percent / acetonitrile / 1.) r.t., 80 min, 2.) 85 deg C, 30 min

With pyridine; water; iodine; In acetonitrile;

Reference yield:

: Diisopropyl-phosphoramidous acid bis-[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

: 173606-88-7
5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(4-chlorobenzyl) phosphotriester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 1H-tetrazole, 2.) H₂O / 1.) CH₃CN, 0 deg C, 30 min, 2.) 25 deg C, 45 min

2: I₂, H₂O, pyridine / 0.25 h / 25 °C

4: 50 percent / acetonitrile / 1.) r.t., 80 min, 2.) 85 deg C, 30 min

With pyridine; 1H-tetrazole; water; iodine; In acetonitrile;