trans-4-[{3-[2-chloro-4-(hydroxymethyl)-5-methoxyphenoxy]propyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

Base Information

Chemical Name:trans-4-[{3-[2-chloro-4-(hydroxymethyl)-5-methoxyphenoxy]propyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate
CAS No.:1346763-32-3
Molecular Formula:C₂₈H₃₄ClNO₆S₂
Molecular Weight:580.166
Hs Code.:

Synonyms:trans-4-[{3-[2-chloro-4-(hydroxymethyl)-5-methoxyphenoxy]propyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

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Chemical Property of trans-4-[{3-[2-chloro-4-(hydroxymethyl)-5-methoxyphenoxy]propyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

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Technology Process of trans-4-[{3-[2-chloro-4-(hydroxymethyl)-5-methoxyphenoxy]propyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

There total 9 articles about trans-4-[{3-[2-chloro-4-(hydroxymethyl)-5-methoxyphenoxy]propyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111300-06-2
trans-tert-butyl 4-hydroxycyclohexylcarbamate

: 1346763-32-3
trans-4-[{3-[2-chloro-4-(hydroxymethyl)-5-methoxyphenoxy]propyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

2: acetonitrile / 20 °C

3: sodium hydride / toluene; mineral oil / 155 °C

4: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

5: triethylamine / acetonitrile; tetrahydrofuran / 40 h / 70 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; toluene; acetonitrile; mineral oil;

Reference yield:

: 7206-70-4
4-amino-5-chloro-2-methoxybenzoic acid

: 1346763-32-3
trans-4-[{3-[2-chloro-4-(hydroxymethyl)-5-methoxyphenoxy]propyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrafluoroboric acid; sodium nitrite / water / 0.5 h / 0 °C

1.2: 3 h / 20 - 100 °C

2.1: acetyl chloride / methanol / 18 h / 60 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Cooling with ice

4.1: potassium carbonate / acetone / 16 h / 75 °C / High pressure

5.1: triethylamine / acetonitrile; tetrahydrofuran / 40 h / 70 °C

With lithium aluminium tetrahydride; tetrafluoroboric acid; potassium carbonate; triethylamine; acetyl chloride; sodium nitrite; In tetrahydrofuran; methanol; water; acetone; acetonitrile;

Reference yield:

: 22348-44-3
trans-4-Methylamino-cyclohexanol

: 1346763-32-3
trans-4-[{3-[2-chloro-4-(hydroxymethyl)-5-methoxyphenoxy]propyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 20 °C

2: sodium hydride / toluene; mineral oil / 155 °C

3: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

4: triethylamine / acetonitrile; tetrahydrofuran / 40 h / 70 °C

With hydrogenchloride; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; toluene; acetonitrile; mineral oil;