Technology Process of 5-(7-chloro-quinolin-4-ylamino)-4'-trifluoromethyl-biphenyl-3-ol
There total 6 articles about 5-(7-chloro-quinolin-4-ylamino)-4'-trifluoromethyl-biphenyl-3-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / H2 / Pd/C / tetrahydrofuran / 2 h / 20 °C / 2068.59 Torr
2: 76 percent / BBr3*Me2S / 1,2-dichloro-ethane / Heating
3: 100 percent / ethanol / 2 h / Heating
With
boron tribromide-dimethyl sulfide complex; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; 1,2-dichloro-ethane;
DOI:10.1021/jm061232x
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 83 percent / N-bromosuccinimide; conc. H2SO4 / 2 h / 80 - 90 °C
2: 82 percent / methanol / 2 h / Heating
3: 92 percent / K2CO3 / palladium(II) acetate / acetone; H2O / 4 h / Heating
4: 100 percent / H2 / Pd/C / tetrahydrofuran / 2 h / 20 °C / 2068.59 Torr
5: 76 percent / BBr3*Me2S / 1,2-dichloro-ethane / Heating
6: 100 percent / ethanol / 2 h / Heating
With
N-Bromosuccinimide; boron tribromide-dimethyl sulfide complex; sulfuric acid; hydrogen; potassium carbonate;
palladium on activated charcoal; palladium diacetate;
In
tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; acetone;
3: Suzuki reaction;
DOI:10.1021/jm061232x