N-{2-[[2-(4-nitrophenyl)allyl]-(3-phenylpropyl)amino]ethyl}-N'-(3-phenylpropyl)ethane-1,2-diamine

Base Information

• Chemical Name: N-{2-[[2-(4-nitrophenyl)allyl]-(3-phenylpropyl)amino]ethyl}-N'-(3-phenylpropyl)ethane-1,2-diamine
• CAS No.: 1391748-68-7
• Molecular Formula: C₃₁H₄₀N₄O₂
• Molecular Weight: 500.684
• Mol file: 1391748-68-7.mol

Synonyms:N-{2-[[2-(4-nitrophenyl)allyl]-(3-phenylpropyl)amino]ethyl}-N'-(3-phenylpropyl)ethane-1,2-diamine

Chemical Property of N-{2-[[2-(4-nitrophenyl)allyl]-(3-phenylpropyl)amino]ethyl}-N'-(3-phenylpropyl)ethane-1,2-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{2-[[2-(4-nitrophenyl)allyl]-(3-phenylpropyl)amino]ethyl}-N'-(3-phenylpropyl)ethane-1,2-diamine

There total 4 articles about N-{2-[[2-(4-nitrophenyl)allyl]-(3-phenylpropyl)amino]ethyl}-N'-(3-phenylpropyl)ethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,2-dimethyl-N-{2-[[2-(4-nitrophenyl)allyl]-(3-phenylpropyl)amino]ethyl}-N-[2-(3-phenylpropylamino)ethyl]propionamide (1391748-77-8) → N-{2-[[2-(4-nitrophenyl)allyl]-(3-phenylpropyl)amino]ethyl}-N'-(3-phenylpropyl)ethane-1,2-diamine (1391748-68-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1002/anie.201200822

Reference yield:

3-phenyl-propionaldehyde (104-53-0) → N-{2-[[2-(4-nitrophenyl)allyl]-(3-phenylpropyl)amino]ethyl}-N'-(3-phenylpropyl)ethane-1,2-diamine (1391748-68-7)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 24 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / ethanol / 24 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / methanol / 72 h / 50 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; ethanol; dichloromethane;

DOI:10.1002/anie.201200822

Reference yield:

C27H37N3O2 → N-{2-[[2-(4-nitrophenyl)allyl]-(3-phenylpropyl)amino]ethyl}-N'-(3-phenylpropyl)ethane-1,2-diamine (1391748-68-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 24 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / methanol / 72 h / 50 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; ethanol; dichloromethane;

DOI:10.1002/anie.201200822

upstream raw materials:

3-phenyl-propionaldehyde

2,2-dimethyl-N,N-bis-[2-(3-phenylpropylamino)ethyl]propionamide

trimethyl-[2-(4-nitrophenyl)allyl]ammonium iodide

2,2-dimethyl-N-{2-[[2-(4-nitrophenyl)allyl]-(3-phenylpropyl)amino]ethyl}-N-[2-(3-phenylpropylamino)ethyl]propionamide