tert-butyl ((7R,8S)-3-(((dimethylamino)methylene)carbamoyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Base Information

Chemical Name:tert-butyl ((7R,8S)-3-(((dimethylamino)methylene)carbamoyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate
CAS No.:1610458-21-3
Molecular Formula:C₂₆H₂₈F₃N₅O₃
Molecular Weight:515.535
Hs Code.:

tert-butyl ((7R,8S)-3-(((dimethylamino)methylene)carbamoyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Synonyms:tert-butyl ((7R,8S)-3-(((dimethylamino)methylene)carbamoyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

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Chemical Property of tert-butyl ((7R,8S)-3-(((dimethylamino)methylene)carbamoyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

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Technology Process of tert-butyl ((7R,8S)-3-(((dimethylamino)methylene)carbamoyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

There total 8 articles about tert-butyl ((7R,8S)-3-(((dimethylamino)methylene)carbamoyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610458-20-2
C₂₃H₂₃F₃N₄O₃

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1610458-21-3
tert-butyl ((7R,8S)-3-(((dimethylamino)methylene)carbamoyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Guidance literature:: for 2h; Reflux;

Reference yield:

: 1384126-46-8
2-bromo-4-nitro-5-(2,4,5-trifluorophenyl)cyclohexanone

: 1610458-21-3
tert-butyl ((7R,8S)-3-(((dimethylamino)methylene)carbamoyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: 2-methyl-propan-1-ol / 5 h / -10 - 0 °C / Reflux

2: zinc; ammonium chloride; acetic acid / water; tetrahydrofuran / 2 h / 50 °C

3: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

4: hydrogenchloride / water / 24 h / 100 °C / pH 12

5: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 2.33 h / 0 - 20 °C

6: triethylamine / tetrahydrofuran / 20 °C

7: 2 h / Reflux

With hydrogenchloride; dihydrogen peroxide; potassium carbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 2-methyl-propan-1-ol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1384175-73-8
(7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxamide

: 1610458-21-3
tert-butyl ((7R,8S)-3-(((dimethylamino)methylene)carbamoyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 20 °C

2: 2 h / Reflux

With triethylamine; In tetrahydrofuran;