Technology Process of (7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxamide
There total 9 articles about (7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dihydrogen peroxide; potassium carbonate;
In
dimethyl sulfoxide;
at 0 - 20 ℃;
for 2.33h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 20 h / 120 °C
2: N-Bromosuccinimide; sodium acetate / water; tetrahydrofuran / 0.5 h / 0 °C
3: 2-methyl-propan-1-ol / 5 h / -10 - 0 °C / Reflux
4: zinc; ammonium chloride; acetic acid / water; tetrahydrofuran / 2 h / 50 °C
5: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C
6: hydrogenchloride / water / 24 h / 100 °C / pH 12
7: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 2.33 h / 0 - 20 °C
With
hydrogenchloride; N-Bromosuccinimide; dihydrogen peroxide; sodium acetate; potassium carbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc;
In
tetrahydrofuran; 2-methyl-propan-1-ol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
1: |Diels-Alder Cycloaddition;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-Bromosuccinimide; sodium acetate / water; tetrahydrofuran / 0.5 h / 0 °C
2: 2-methyl-propan-1-ol / 5 h / -10 - 0 °C / Reflux
3: zinc; ammonium chloride; acetic acid / water; tetrahydrofuran / 2 h / 50 °C
4: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C
5: hydrogenchloride / water / 24 h / 100 °C / pH 12
6: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 2.33 h / 0 - 20 °C
With
hydrogenchloride; N-Bromosuccinimide; dihydrogen peroxide; sodium acetate; potassium carbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc;
In
tetrahydrofuran; 2-methyl-propan-1-ol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
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