N-(N-methyl-L-valyl-L-tyrosyl)-1-amino-2-(4-hydoxyphenyl)ethylphosphonic acid

Base Information

Chemical Name:N-(N-methyl-L-valyl-L-tyrosyl)-1-amino-2-(4-hydoxyphenyl)ethylphosphonic acid
CAS No.:1557193-39-1
Molecular Formula:C₂₃H₃₂N₃O₇P
Molecular Weight:493.497
Hs Code.:

Synonyms:N-(N-methyl-L-valyl-L-tyrosyl)-1-amino-2-(4-hydoxyphenyl)ethylphosphonic acid

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Chemical Property of N-(N-methyl-L-valyl-L-tyrosyl)-1-amino-2-(4-hydoxyphenyl)ethylphosphonic acid

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Technology Process of N-(N-methyl-L-valyl-L-tyrosyl)-1-amino-2-(4-hydoxyphenyl)ethylphosphonic acid

There total 5 articles about N-(N-methyl-L-valyl-L-tyrosyl)-1-amino-2-(4-hydoxyphenyl)ethylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.2%

: diethyl N-(N-methyl-L-valyl-L-tyrosyl)-1-amino-2-(4-hydoxyphenyl)ethylphosphonate

: 1557193-39-1,93768-49-1
N-(N-methyl-L-valyl-L-tyrosyl)-1-amino-2-(4-hydoxyphenyl)ethylphosphonic acid

Guidance literature:: With trimethylsilyl iodide; methyl-phenyl-thioether; In acetonitrile; at 0 ℃; for 3h;
DOI:10.1021/ml4004588

Reference yield:

: 42417-65-2
Z-MeVal-OH

: 1557193-39-1,93768-49-1
N-(N-methyl-L-valyl-L-tyrosyl)-1-amino-2-(4-hydoxyphenyl)ethylphosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,4,6-trimethyl-pyridine / N,N-dimethyl-formamide / 0 - 20 °C

2: sodium carbonate / acetonitrile; water / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,4,6-trimethyl-pyridine / N,N-dimethyl-formamide / 0 - 20 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

5: methyl-phenyl-thioether; trimethylsilyl iodide / acetonitrile / 3 h / 0 °C

With 2,4,6-trimethyl-pyridine; trimethylsilyl iodide; methyl-phenyl-thioether; palladium 10% on activated carbon; hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml4004588

Reference yield:

: 1557198-63-6
N-benzyloxycarbonyl-N-methyl-L-valyl-O-benzyl-L-tyrosine methyl ester

: 1557193-39-1,93768-49-1
N-(N-methyl-L-valyl-L-tyrosyl)-1-amino-2-(4-hydoxyphenyl)ethylphosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / acetonitrile; water / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,4,6-trimethyl-pyridine / N,N-dimethyl-formamide / 0 - 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

4: methyl-phenyl-thioether; trimethylsilyl iodide / acetonitrile / 3 h / 0 °C

With 2,4,6-trimethyl-pyridine; trimethylsilyl iodide; methyl-phenyl-thioether; palladium 10% on activated carbon; hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml4004588