4'-Hydroxymethyl-3,4-dimethoxy-6-methyl-bicyclohexyl-3,6-diene-2,5-dione

Base Information

• Chemical Name: 4'-Hydroxymethyl-3,4-dimethoxy-6-methyl-bicyclohexyl-3,6-diene-2,5-dione
• CAS No.: 144851-04-7
• Molecular Formula: C₁₆H₂₂O₅
• Molecular Weight: 294.348
• Mol file: 144851-04-7.mol

Synonyms:4'-Hydroxymethyl-3,4-dimethoxy-6-methyl-bicyclohexyl-3,6-diene-2,5-dione

Chemical Property of 4'-Hydroxymethyl-3,4-dimethoxy-6-methyl-bicyclohexyl-3,6-diene-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-Hydroxymethyl-3,4-dimethoxy-6-methyl-bicyclohexyl-3,6-diene-2,5-dione

There total 12 articles about 4'-Hydroxymethyl-3,4-dimethoxy-6-methyl-bicyclohexyl-3,6-diene-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-Hydroxymethyl-cyclohexyl)-5,6-dimethoxy-3-methyl-benzene-1,4-diol → 4'-Hydroxymethyl-3,4-dimethoxy-6-methyl-bicyclohexyl-3,6-diene-2,5-dione (144851-04-7)

Guidance literature:

With iron(III) chloride; In tetrahydrofuran; hydrogenchloride; diethyl ether; for 1h; Yield given; Heating;

DOI:10.1021/jo970752k

Reference yield:

2,3-Dimethoxy-5-methyl-1,4-benzoquinone (605-94-7) → 4'-Hydroxymethyl-3,4-dimethoxy-6-methyl-bicyclohexyl-3,6-diene-2,5-dione (144851-04-7)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium peroxodisulfate, AgNO₃ / H₂O; CH₂Cl₂ / Heating

2: Na₂S₂O₄ / H₂O; CH₂Cl₂

3: LiBH₄ / tetrahydrofuran / 20 h / Heating

4: FeCl₃ / tetrahydrofuran; aq. HCl; diethyl ether / 1 h / Heating

With ammonium persulfate; lithium borohydride; sodium dithionite; iron(III) chloride; silver nitrate; In tetrahydrofuran; hydrogenchloride; diethyl ether; dichloromethane; water;

DOI:10.1021/jo970752k

Reference yield:

4-(methoxycarbonyl)cyclohexanecarboxylic acid (32529-79-6) → 4'-Hydroxymethyl-3,4-dimethoxy-6-methyl-bicyclohexyl-3,6-diene-2,5-dione (144851-04-7)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium peroxodisulfate, AgNO₃ / H₂O; CH₂Cl₂ / Heating

2: Na₂S₂O₄ / H₂O; CH₂Cl₂

3: LiBH₄ / tetrahydrofuran / 20 h / Heating

4: FeCl₃ / tetrahydrofuran; aq. HCl; diethyl ether / 1 h / Heating

With ammonium persulfate; lithium borohydride; sodium dithionite; iron(III) chloride; silver nitrate; In tetrahydrofuran; hydrogenchloride; diethyl ether; dichloromethane; water;

DOI:10.1021/jo970752k

upstream raw materials:

2-(4-Hydroxymethyl-cyclohexyl)-5,6-dimethoxy-3-methyl-benzene-1,4-diol

2,3-Dimethoxy-5-methyl-1,4-benzoquinone

4-(methoxycarbonyl)cyclohexanecarboxylic acid

4',5'-Dimethoxy-2'-methyl-3',6'-dioxo-bicyclohexyl-1',4'-diene-4-carboxylic acid methyl ester

Downstream raw materials:

2-(4-formylcyclohexyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone