32529-79-6Relevant academic research and scientific papers
POLYMERIZABLE COMPOUND, COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, LIQUID CRYSTAL DISPLAY ELEMENT, AND ORGANIC EL DEVICE
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Paragraph 0152; 0153, (2017/09/25)
It is an object of the present invention to provide a polymerizable compound having a good liquid crystal property, a good alignment property, sufficient solubility in solvents, high preservation stability in a solution state, and high optical stability; a composition including the polymerizable compound; a polymer produced by polymerizing the polymerizable compound, such as a resin produced using the polymerizable compound; an optically anisotropic body including the polymer; and a liquid crystal display element and an organic EL device that include the optically anisotropic body. As a result of conducting intensive studies in order to achieve the above object, the compound represented by General Formula (I) is developed.
3-CYCLOHEXENYL AND CYCLOHEXYL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
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Paragraph 0294, (2015/07/15)
The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.
3-CYCLOHEXENYL AND CYCLOHEXYL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
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Page/Page column 54, (2014/03/22)
The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.
Structure-activity relationships of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase
Kim, In-Hae,Park, Yong-Kyu,Hammock, Bruce D.,Nishi, Kosuke
experimental part, p. 1752 - 1761 (2011/05/05)
Structure-activity relationships of cycloalkylamide compounds as inhibitors of human sEH were investigated. When the left side of amide function was modified by a variety of cycloalkanes, at least a C6 like cyclohexane was necessary to yield reasonable inhibition potency on the target enzyme. In compounds with a smaller cycloalkane or with a polar group on the left side of amide function, no inhibition was observed. On the other hand, increased hydrophobicity dramatically improved inhibition potency. Especially, a tetrahydronaphthalene (20) effectively increased the potency. When a series of alkyl or aryl derivatives of cycloalkylamide were investigated to continuously optimize the right side of the amide pharmacophore, a benzyl moiety functionalized with a polar group produced highly potent inhibition. A nonsubstituted benzyl, alkyl, aryl, or biaryl structure present on the right side of the cycloalkylamide function induced a big decrease in inhibition potency. Also, the resulting potent cycloalkylamide (32) showed reasonable physical properties.
Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists
Sakamoto, Toshihiro,Moriya, Minoru,Haga, Yuji,Takahashi, Toshiyuki,Shibata, Takunobu,Okamoto, Osamu,Nonoshita, Katsumasa,Kitazawa, Hidefumi,Hidaka, Masayasu,Gomori, Akira,Iwaasa, Hisashi,Ishihara, Akane,Kanatani, Akio,Fukami, Takehiro,Gao, Ying-Duo,MacNeil, Douglas J.,Yang, Lihu
scheme or table, p. 1564 - 1568 (2009/12/07)
A series of spiroindoline-3,4′-piperidine derivatives were synthesized and evaluated for their binding affinities and antagonistic activities at Y5 receptors. Potent Y5 antagonists were tested for their oral bioavailabilities and brain penetration in rats
PROCESS FOR THE PREPARATION OF 6, 8-SUBSTITUTED `1, 7 NAPHTHPYRIDIN DERIVATIVES BY REACTING THE 8-HALO-`1, 7 NAPHTHPYRIDIN-DERIVATE WITH AN ORGANIC BORONIC ACID DERIVATIVES AND INTERMADIATES OF THIS PROCESS
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Page/Page column 13-14, (2010/10/20)
A process for the preparation of compounds of formula (I) wherein R1 is C1-C20-alkyl optionally substituted by one or two of hydroxy, C3-C12-cycloalkyl, C6-C12-aryl, C1/sub
Synthesis of Porphyrin Quinones with Aliphatic and Cycloaliphatic Bridges as Model Compounds for Studying the Light-Induced Charge Separation in Photosynthesis
Gersdorff, Joerg von,Kirste, Burkhard,Kurreck, Harry
, p. 897 - 904 (2007/10/02)
Covalently linked porphyrin quinones (P-Qs) are well-suited as biomimetic model compounds in studying the light-induced charge separation occurring in primary processes of photosynthesis.We report on a synthetic strategy which leads to P-Qs with the porphyrin donor covalently linked to the quinone acceptor via aliphatic and cycloaliphatic spacers.Preparation of two diastereomeric cyclohexylene-bridged P-Qs 1 and 2 and of 3 bearing a butylene spacer is described.Structures, including the spatial arrangements of the donor, bridge and acceptor, are determined by various NMR techniques.These data are compared with those deduced from simple force-field calculations using the molecular modelling program ALCHEMY II (Tripos Associates) and MNDO (MOPAC-6) calculations. Key words: Porphyrins; quinones; cyclohexanes, 1,4-disubstituted; photochemistry; calculations, force-field, MNDO.
Pesticidal compounds
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, (2008/06/13)
The present invention provides a class of novel substituted bicyclooctanes which have pesticidal activity, particularly against arthropod pests. Pesticidal formulations containing the compounds of the formula (I), their use in the control of pests and methods for their preparation are also disclosed.
