ethyl 3-{3-[2-(4-chlorophenylsulphonylamino)ethyl]-5-(pyridin-4-ylmethyl)phenyl}propanoate

Base Information

• Chemical Name: ethyl 3-{3-[2-(4-chlorophenylsulphonylamino)ethyl]-5-(pyridin-4-ylmethyl)phenyl}propanoate
• CAS No.: 145690-85-3
• Molecular Formula: C₂₅H₂₇ClN₂O₄S
• Molecular Weight: 487.019
• Mol file: 145690-85-3.mol

Synonyms:ethyl 3-{3-[2-(4-chlorophenylsulphonylamino)ethyl]-5-(pyridin-4-ylmethyl)phenyl}propanoate

Chemical Property of ethyl 3-{3-[2-(4-chlorophenylsulphonylamino)ethyl]-5-(pyridin-4-ylmethyl)phenyl}propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-{3-[2-(4-chlorophenylsulphonylamino)ethyl]-5-(pyridin-4-ylmethyl)phenyl}propanoate

There total 5 articles about ethyl 3-{3-[2-(4-chlorophenylsulphonylamino)ethyl]-5-(pyridin-4-ylmethyl)phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-chlorobenzenesulfonyl chloride (98-60-2) + 3-[3-(2-Amino-ethyl)-5-pyridin-4-ylmethyl-phenyl]-propionic acid ethyl ester (145691-98-1) → ethyl 3-{3-[2-(4-chlorophenylsulphonylamino)ethyl]-5-(pyridin-4-ylmethyl)phenyl}propanoate (145690-85-3)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/S0960-894X(98)00242-X

Reference yield:

3-[3-(2-Ethoxycarbonyl-ethyl)-5-pyridin-4-ylmethyl-phenyl]-propionic acid (145691-82-3) → ethyl 3-{3-[2-(4-chlorophenylsulphonylamino)ethyl]-5-(pyridin-4-ylmethyl)phenyl}propanoate (145690-85-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / diphenylphosphoryl azide, Et₃N

2: 75 percent / TFA / CH₂Cl₂

3: 86 percent / Et₃N / CH₂Cl₂

With diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0960-894X(98)00242-X

Reference yield:

3-[3-(2-Ethoxycarbonyl-ethyl)-5-pyridin-4-ylmethyl-phenyl]-propionic acid ethyl ester → ethyl 3-{3-[2-(4-chlorophenylsulphonylamino)ethyl]-5-(pyridin-4-ylmethyl)phenyl}propanoate (145690-85-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 41 percent / aq. NaOH / ethanol

2: 76 percent / diphenylphosphoryl azide, Et₃N

3: 75 percent / TFA / CH₂Cl₂

4: 86 percent / Et₃N / CH₂Cl₂

With sodium hydroxide; diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;

DOI:10.1016/S0960-894X(98)00242-X

upstream raw materials:

4-chlorobenzenesulfonyl chloride

3-[3-(2-Amino-ethyl)-5-pyridin-4-ylmethyl-phenyl]-propionic acid ethyl ester

3-[3-(2-Ethoxycarbonyl-ethyl)-5-pyridin-4-ylmethyl-phenyl]-propionic acid

3-[3-(2-tert-Butoxycarbonylamino-ethyl)-5-pyridin-4-ylmethyl-phenyl]-propionic acid ethyl ester