2,4-dichloro-5-(trifluoromethyl)-3-(trimethylsilyl)benzoic acid

Base Information

• Chemical Name: 2,4-dichloro-5-(trifluoromethyl)-3-(trimethylsilyl)benzoic acid
• CAS No.: 871254-71-6
• Molecular Formula: C₁₁H₁₁Cl₂F₃O₂Si
• Molecular Weight: 331.194
• Mol file: 871254-71-6.mol

Synonyms:2,4-dichloro-5-(trifluoromethyl)-3-(trimethylsilyl)benzoic acid

Chemical Property of 2,4-dichloro-5-(trifluoromethyl)-3-(trimethylsilyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2,4-dichloro-5-(trifluoromethyl)-3-(trimethylsilyl)benzoic acid

There total 5 articles about 2,4-dichloro-5-(trifluoromethyl)-3-(trimethylsilyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

[3-bromo-2,6-dichloro-5-(trifluoromethyl)phenyl]trimethylsilane (871254-73-8) + carbon dioxide (124-38-9,18923-20-1) → 2,4-dichloro-5-(trifluoromethyl)-3-(trimethylsilyl)benzoic acid (871254-71-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -100 ℃;

DOI:10.1002/ejoc.200500240

Reference yield: 42.0%

[2,6-dichloro-3-(trifluoromethyl)phenyl]trimethylsilane (871254-70-5) + carbon dioxide (124-38-9,18923-20-1) → 2,4-dichloro-5-(trifluoromethyl)-3-(trimethylsilyl)benzoic acid (871254-71-6)

Guidance literature:

With N,N,N',N'',N'''-pentamethyldiethylenetriamine; sec.-butyllithium; In tetrahydrofuran; at -100 ℃;

DOI:10.1002/ejoc.200500240

Reference yield:

2,4-dichloro-benzotrifluoride (320-60-5) → 2,4-dichloro-5-(trifluoromethyl)-3-(trimethylsilyl)benzoic acid (871254-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / BuLi / hexane; tetrahydrofuran / -75 °C

2: 42 percent / sBuLi; N,N',N',N'',N''-pentamethyldiethylenetriamine / tetrahydrofuran / -100 °C

With n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine; sec.-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1002/ejoc.200500240

upstream raw materials:

[2,6-dichloro-3-(trifluoromethyl)phenyl]trimethylsilane

carbon dioxide

[3-bromo-2,6-dichloro-5-(trifluoromethyl)phenyl]trimethylsilane

2-bromo-1,3-dichloro-4-(trifluoromethyl)benzene