(4R)-1,4-dihydro-3-(2-cyanoethyl)oxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid

Base Information

• Chemical Name: (4R)-1,4-dihydro-3-(2-cyanoethyl)oxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid
• CAS No.: 152375-53-6
• Molecular Formula: C₁₈H₁₇N₃O₆
• Molecular Weight: 371.349

Synonyms:(4R)-1,4-dihydro-3-(2-cyanoethyl)oxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid

Chemical Property of (4R)-1,4-dihydro-3-(2-cyanoethyl)oxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid

Chemical Property:

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Technology Process of (4R)-1,4-dihydro-3-(2-cyanoethyl)oxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid

There total 2 articles about (4R)-1,4-dihydro-3-(2-cyanoethyl)oxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

bis(2-cyanoethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine 3,5-dicarboxylate → (4R)-1,4-dihydro-3-(2-cyanoethyl)oxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid (152375-53-6)

Guidance literature:

In dimethyl sulfoxide; for 72h; Ambient temperature; seaprose S_. (Aspergillus mellens), phosphate buffer pH 7.8;

DOI:10.1016/S0040-4039(00)79178-7

Reference yield:

bis(2-cyanoethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine 3,5-dicarboxylate + alkaline protease → (4R)-1,4-dihydro-3-(2-cyanoethyl)oxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid (152375-53-6)

Guidance literature:

In dimethyl sulfoxide; ethyl acetate; acetone;

Reference yield:

chloromethyl methyl ether (107-30-2) + (4R)-1,4-dihydro-3-(2-cyanoethyl)oxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid (152375-53-6) → methoxymethyl (4S)-5-(2-cyanoethoxycarbonyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3-carboxylate

Guidance literature:

With potassium carbonate; In ethyl acetate; N,N-dimethyl-formamide;

Downstream raw materials:

2-cyanoethyl (R)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-3-pyridinecarboxylate

(+)-(S)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)pyridine-3-carboxylic acid

2-tetrahydropyranyl (4s)-5-(2-cyanoethoxycarbonyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3-carboxylate

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