2-cyanoethyl (R)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-3-pyridinecarboxylate

Base Information

Chemical Name:2-cyanoethyl (R)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-3-pyridinecarboxylate
CAS No.:143167-32-2
Molecular Formula:C₁₉H₁₉N₃O₆
Molecular Weight:385.376
Hs Code.:

Synonyms:2-cyanoethyl (R)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-3-pyridinecarboxylate

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Chemical Property of 2-cyanoethyl (R)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-3-pyridinecarboxylate

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Technology Process of 2-cyanoethyl (R)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-3-pyridinecarboxylate

There total 5 articles about 2-cyanoethyl (R)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: bis(2-cyanoethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine 3,5-dicarboxylate

: 143167-32-2
2-cyanoethyl (R)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-3-pyridinecarboxylate

Guidance literature:: With phosphate buffer; In water; at 30 ℃; for 120h; seaprose S (Aspergillus melleus) catalyst; pH 7.8;
DOI:10.1016/S0040-4039(00)73813-5

Reference yield:

: 75130-24-4
2,6-dimethyl-4-(3-nitrophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylic acid 2-cyanoethyl ester

: 114208-23-0
(+)-2-cyanoethyl methyl (S)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

: 143167-32-2
2-cyanoethyl (R)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-3-pyridinecarboxylate

Guidance literature:: With Chiralpak AS; In ethanol; hexane; isopropyl alcohol; Resolution of racemate;
DOI:10.1016/j.bmc.2010.03.038

Reference yield:

: bis(2-cyanoethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine 3,5-dicarboxylate

: 143167-32-2
2-cyanoethyl (R)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / dimethylsulfoxide / 72 h / Ambient temperature; seaprose S_. (Aspergillus mellens), phosphate buffer pH 7.8; other substrates, other proteases; enantioselectivity

2: CH₂Cl₂

In dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)79178-7