(S)-1-((S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid

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Chemical Name:(S)-1-((S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid
CAS No.:172837-42-2
Molecular Formula:C₂₉H₄₄N₄O₇
Molecular Weight:560.691
Hs Code.:

(S)-1-((S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid

Synonyms:(S)-1-((S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid

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Chemical Property of (S)-1-((S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid

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Technology Process of (S)-1-((S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid

There total 8 articles about (S)-1-((S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 172837-42-2
(S)-1-((S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / diisopropylethylamine, tripyrrolidinobromophosphonium hexafluorophosphate / CH₂Cl₂ / 1 h / Ambient temperature

2: H₂, 12N HCl / 10percent Pd/C / methanol / 16 h / 760 Torr / Ambient temperature

3: 84 percent / diisopropylethylamine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 1 h / Ambient temperature

4: 3N HCl / dioxane / 5 h

With hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm970800t

Reference yield:

: 42417-65-2
Z-MeVal-OH

: 172837-42-2
(S)-1-((S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / diisopropylethylamine, tripyrrolidinobromophosphonium hexafluorophosphate / CH₂Cl₂ / 1 h / Ambient temperature

2: 99 percent / H₂, 12N HCl / 10percent Pd/C / methanol / 16 h / 760 Torr / Ambient temperature

3: 93 percent / diisopropylethylamine, tripyrrolidinobromophosphonium hexafluorophosphate / CH₂Cl₂ / 1 h / Ambient temperature

4: H₂, 12N HCl / 10percent Pd/C / methanol / 16 h / 760 Torr / Ambient temperature

5: 84 percent / diisopropylethylamine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 1 h / Ambient temperature

6: 3N HCl / dioxane / 5 h

With hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm970800t

Reference yield:

: 2812-46-6
proline tert-butyl ester

: 172837-42-2
(S)-1-((S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / diisopropylethylamine, tripyrrolidinobromophosphonium hexafluorophosphate / CH₂Cl₂ / 1 h / Ambient temperature

2: 99 percent / H₂, 12N HCl / 10percent Pd/C / methanol / 16 h / 760 Torr / Ambient temperature

3: 93 percent / diisopropylethylamine, tripyrrolidinobromophosphonium hexafluorophosphate / CH₂Cl₂ / 1 h / Ambient temperature

4: H₂, 12N HCl / 10percent Pd/C / methanol / 16 h / 760 Torr / Ambient temperature

5: 84 percent / diisopropylethylamine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 1 h / Ambient temperature

6: 3N HCl / dioxane / 5 h

With hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm970800t