tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate

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Chemical Name:tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate
CAS No.:1307895-79-9
Molecular Formula:C₂₄H₂₇N₅O₃
Molecular Weight:433.51
Hs Code.:

Synonyms:tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate

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Chemical Property of tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate

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Technology Process of tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate

There total 7 articles about tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 4-amino-7-(3-(tert-butyldimethylsilyloxy)propyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde

: 1116-98-9
cyanoacetic acid tert-butyl ester

: 1307895-79-9
tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate

Guidance literature:: 4-amino-7-(3-(tert-butyldimethylsilyloxy)propyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde; cyanoacetic acid tert-butyl ester; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; In water;

Reference yield:

: 1307896-58-7
N'-(3-cyano-4-p-tolyl-1H-pyrrol-2-yl)formimidamide

: 1307895-79-9
tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / methanol / 3 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

2.2: 4 h

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 24 h

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 3 h / Inert atmosphere

5.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / 20 °C

With sodium periodate; N-Bromosuccinimide; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 1307896-57-6
methyl N-3-cyano-4-p-tolyl-1H-pyrrol-2-ylformimidate

: 1307895-79-9
tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonia / methanol / 4 h / 20 °C

2.1: sodium methylate / methanol / 3 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 4 h

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 24 h

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 3 h / Inert atmosphere

6.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / 20 °C

With sodium periodate; N-Bromosuccinimide; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium methylate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;