[2-bromomethyl-1-(toluene-4-sulfonyl)aziridin-2-ylmethylene]-cyclohexylamine

Base Information

Chemical Name:[2-bromomethyl-1-(toluene-4-sulfonyl)aziridin-2-ylmethylene]-cyclohexylamine
CAS No.:1428766-63-5
Molecular Formula:C₁₇H₂₃BrN₂O₂S
Molecular Weight:399.352
Hs Code.:

Synonyms:[2-bromomethyl-1-(toluene-4-sulfonyl)aziridin-2-ylmethylene]-cyclohexylamine

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Chemical Property of [2-bromomethyl-1-(toluene-4-sulfonyl)aziridin-2-ylmethylene]-cyclohexylamine

Chemical Property:

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Technology Process of [2-bromomethyl-1-(toluene-4-sulfonyl)aziridin-2-ylmethylene]-cyclohexylamine

There total 6 articles about [2-bromomethyl-1-(toluene-4-sulfonyl)aziridin-2-ylmethylene]-cyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1428766-59-9
2-bromomethyl-1-tosylaziridine-2-carboxaldehyde

: 108-91-8,157973-60-9
cyclohexylamine

: 1428766-63-5
[2-bromomethyl-1-(toluene-4-sulfonyl)aziridin-2-ylmethylene]-cyclohexylamine

Guidance literature:: With magnesium sulfate; In dichloromethane; for 2h; Reflux;
DOI:10.1016/j.tet.2013.02.065

Reference yield:

: 1092540-02-7
ethyl 2-{[(4-methylbenzene)sulfonamido]methyl}acrylate

: 1428766-63-5
[2-bromomethyl-1-(toluene-4-sulfonyl)aziridin-2-ylmethylene]-cyclohexylamine

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / dichloromethane / 24 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 2 h / 60 °C

3: lithium aluminium tetrahydride / diethyl ether / 1 h / -78 °C

4: magnesium sulfate / dichloromethane / 2 h / Reflux

With lithium aluminium tetrahydride; bromine; magnesium sulfate; potassium carbonate; In diethyl ether; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2013.02.065

Reference yield:

: 1428766-57-7
ethyl 2-({(N-tert-butoxycarbonyl)[N-toluene-4-sulfonyl]amino}methyl)prop-2-enoate

: 1428766-63-5
[2-bromomethyl-1-(toluene-4-sulfonyl)aziridin-2-ylmethylene]-cyclohexylamine

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

2: bromine / dichloromethane / 24 h / 0 - 20 °C

3: potassium carbonate / acetonitrile / 2 h / 60 °C

4: lithium aluminium tetrahydride / diethyl ether / 1 h / -78 °C

5: magnesium sulfate / dichloromethane / 2 h / Reflux

With lithium aluminium tetrahydride; bromine; magnesium sulfate; potassium carbonate; trifluoroacetic acid; In diethyl ether; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2013.02.065