3-(biphenyl-4-ylsulfanyl)-propionic acid 2-ethyl-hexyl ester

Base Information

• Chemical Name: 3-(biphenyl-4-ylsulfanyl)-propionic acid 2-ethyl-hexyl ester
• CAS No.: 1026904-14-2
• Molecular Formula: C₂₃H₃₀O₂S
• Molecular Weight: 370.556
• Mol file: 1026904-14-2.mol

Synonyms:3-(biphenyl-4-ylsulfanyl)-propionic acid 2-ethyl-hexyl ester

Chemical Property of 3-(biphenyl-4-ylsulfanyl)-propionic acid 2-ethyl-hexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(biphenyl-4-ylsulfanyl)-propionic acid 2-ethyl-hexyl ester

There total 3 articles about 3-(biphenyl-4-ylsulfanyl)-propionic acid 2-ethyl-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-bromoiodobenzene (589-87-7) → 3-(4-formylphenylsulfanyl)propionic acid 2-ethylhexyl ester + 3-(biphenyl-4-ylsulfanyl)-propionic acid 2-ethyl-hexyl ester (1026904-14-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / Pd₂(dba)3; Xantphos; i-Pr₂NEt / toluene / 15 h / Heating

2: 84 percent / Pd₂(dba)3; t-BuONa; D-t-BPF / toluene / 6 h / Heating

3: 100 percent / EtONa / ethanol / 5 h / 20 °C

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; D-t-BPF; sodium ethanolate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In ethanol; toluene; 2: Buchwald-Hartwig reaction;

DOI:10.1021/jo052624z

Reference yield:

1,4-bromoiodobenzene (589-87-7) → 3-(4-formylphenylsulfanyl)propionic acid 2-ethylhexyl ester + 3-(biphenyl-4-ylsulfanyl)-propionic acid 2-ethyl-hexyl ester (1026904-14-2) + 3-(4'-methoxy-biphenyl-4-ylsulfanyl)-propionic acid 2-ethyl-hexyl ester + 3-(4'-fluoro-biphenyl-4-ylsulfanyl)-propionic acid 2-ethyl-hexyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / Pd₂(dba)3; Xantphos; i-Pr₂NEt / toluene / 15 h / Heating

2: 84 percent / Pd₂(dba)3; t-BuONa; D-t-BPF / toluene / 6 h / Heating

3: 100 percent / EtONa / ethanol / 5 h / 20 °C

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; D-t-BPF; sodium ethanolate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In ethanol; toluene; 2: Buchwald-Hartwig reaction;

DOI:10.1021/jo052624z

Reference yield:

1,4-bromoiodobenzene (589-87-7) → 3-(4-formylphenylsulfanyl)propionic acid 2-ethylhexyl ester + 3-(biphenyl-4-ylsulfanyl)-propionic acid 2-ethyl-hexyl ester (1026904-14-2) + 3-(4'-methoxy-biphenyl-4-ylsulfanyl)-propionic acid 2-ethyl-hexyl ester + 3-(4'-fluoro-biphenyl-4-ylsulfanyl)-propionic acid 2-ethyl-hexyl ester + 3-(4-styryl-phenylsulfanyl)propionic acid 2-ethylhexyl ester (881664-13-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 44.3 percent / copper / 4 h / 150 - 175 °C

2: 48.5 percent / triethylphosphite / 20 h / 165 °C

3: 30.6 percent / N,N-dimethyl-acetamide / 18 h / Heating

With copper; triethyl phosphite; In N,N-dimethyl acetamide; 1: Ullmann reaction;

DOI:10.1128/AAC.46.3.797-807.2002

upstream raw materials:

1,4-bromoiodobenzene

Downstream raw materials:

4-biphenylthiol