5-(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)-1-methyl-1H-imidazole

Base Information

Chemical Name:5-(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)-1-methyl-1H-imidazole
CAS No.:1616248-96-4
Molecular Formula:C₁₈H₁₈N₂O
Molecular Weight:278.354
Hs Code.:

Synonyms:5-(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)-1-methyl-1H-imidazole

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Chemical Property of 5-(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)-1-methyl-1H-imidazole

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Technology Process of 5-(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)-1-methyl-1H-imidazole

There total 4 articles about 5-(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)-1-methyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: 1616249-18-3
(E)-N-((3-methoxy-2′-methyl(1,1′-biphenyl)-4-yl)-methylene)methanamine

: 1616248-96-4
5-(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)-1-methyl-1H-imidazole

Guidance literature:: With potassium carbonate; In methanol; at 0 - 20 ℃; for 16h; Molecular sieve;
DOI:10.1039/c4ob00647j

Reference yield:

: 89-86-1
4-hydroxysalicylic acid

: 1616248-96-4
5-(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)-1-methyl-1H-imidazole

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid / 18 h / Reflux

2: pyridine / dichloromethane / 24 h

3: caesium carbonate / tetrahydrofuran

4: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 130 °C / Microwave irradiation

5: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 20 °C

6: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 14 h / Molecular sieve; Reflux

7: ethanol / 24 h / 20 °C / Molecular sieve

8: potassium carbonate / methanol / 16 h / 0 - 20 °C / Molecular sieve

With pyridine; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; sodium carbonate; potassium carbonate; caesium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; 4: |Suzuki Coupling;
DOI:10.1039/c4ob00647j

Reference yield:

: 4143-00-4
ethyl 2,4-dihydroxybenzoate

: 1616248-96-4
5-(3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)-1-methyl-1H-imidazole

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / dichloromethane / 24 h

2: caesium carbonate / tetrahydrofuran

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 130 °C / Microwave irradiation

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 20 °C

5: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 14 h / Molecular sieve; Reflux

6: ethanol / 24 h / 20 °C / Molecular sieve

7: potassium carbonate / methanol / 16 h / 0 - 20 °C / Molecular sieve

With pyridine; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; caesium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; 3: |Suzuki Coupling;
DOI:10.1039/c4ob00647j