4143-00-4

Basic information

• Product Name: ETHYL 2,4-DIHYDROXYBENZOATE
• Synonyms: RARECHEM AL BI 0221;ETHYL 2,4-DIHYDROXYBENZOATE;Benzoic acid, 2,4-dihydroxy-, ethyl ester
• CAS NO: 4143-00-4
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.17
• Mol File: 4143-00-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 69-72 °C(lit.)
• Boiling Point: 358.5°C at 760 mmHg
• Flash Point: 147.2°C
• Appearance: /
• Density: 1.294g/cm³
• Vapor Pressure: 1.23E-05mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: ETHYL 2,4-DIHYDROXYBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,4-DIHYDROXYBENZOATE(4143-00-4)
• EPA Substance Registry System: ETHYL 2,4-DIHYDROXYBENZOATE(4143-00-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 4143-00-4(Hazardous Substances Data)

Usage

General Description

Ethyl 2,4-dihydroxybenzoate, also known as ethyl protocatechuate, is a chemical compound with the molecular formula C10H12O4. It is an ester of protocatechuic acid and ethyl alcohol. ETHYL 2,4-DIHYDROXYBENZOATE is commonly used in the pharmaceutical and cosmetic industries as an ingredient in various products, including sunscreen, anti-aging creams, and analgesic medications. Ethyl 2,4-dihydroxybenzoate is known for its antioxidant properties and is often used as a preservative in skincare products. It has also been studied for potential therapeutic applications, such as its anti-inflammatory and anticancer effects. However, further research is needed to fully understand its potential benefits and risks.

InChI:InChI=1/C9H10O4/c1-2-13-9(12)7-4-3-6(10)5-8(7)11/h3-5,10-11H,2H2,1H3

Upstream product

• 89-86-1 4-hydroxysalicylic acid 
• 64-17-5 ethanol 
• 57438-38-7 2,4-dihydroxybenzoyl chloride 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 

Downstream Products

• 1032990-30-9 ethyl 2-hydroxy-4-(octyloxy)benzoate 
• 1032990-32-1 2-(allyloxy)-4-(octyloxy)benzoic acid 
• 1432034-19-9 4-(4-propylcyclohexyl)phenyl 2-(allyloxy)-4-(octyloxy)benzoate 
• 1432034-20-2 4-(4-propylcyclohexyl)phenyl 2-(but-3-enyloxy)-4-(octyloxy)benzoate 
• 1032990-25-2 C₃₃H₄₀O₄ 
• 1032990-31-0 ethyl 2-(allyloxy)-4-(octyloxy)benzoate 
• 1432034-18-8 ethyl 2-(but-3-enyloxy)-4-(octyloxy)benzoate 
• 304481-57-0 C₁₂H₉N₃O₆ 
• 1616249-05-8 ethyl 2-hydroxy-4-(trifluoromethylsulfonyloxy)benzoate 
• 1616249-17-2 ethyl 2,4-bis(((trifluoromethyl)sulfonyl)oxy)benzoate 
• 1616249-00-3 2-(3-methoxy-2′-methyl[1,1′-biphenyl]-4-yl)-5-methyl-1,3,4-oxadiazole 
• 1616248-99-7 2-(2-methoxy-4-(4-methylpyridin-3-yl)phenyl)-5-methyl-1,3,4-oxadiazole 
• 1616248-98-6 (3-methoxy-2′-methyl-[1,1′-biphenyl]-4-yl)(3-methylpiperazin-1-yl)methanone 
• 1616249-14-9 tert-butyl 4-(2-methoxy-4-(4-methylpyridin-3-yl)benzoyl)-2-methylpiperazine-1-carboxylate 

Relevant articles and documents

Synthesis, protolytic equilibria, and antimicrobial action of nifuroxazide analogs

The present paper reports on the synthesis of four hydrazones derived from 5-nitro-2-furfural, 5-nitro-2-thiophenal, isoniazid, 2,4- and 3,4-dihydroxy-N′-methylenebenzohydrazide. The acid-base dissociation constants of these compounds were determined in an aqueous solution. The protolytic equilibria-related ability of hydrazones to “sense” anions in dimethyl sulfoxide-containing water of different concentrations is studied using spectrophotometry, NMR spectroscopy, and quantum chemistry methods. The antimicrobial action of the hydrazones was tested and compared with that of the known drug nifuroxazide.

Novel chemoselective de-esterification of esters of polyacetoxy aromatic acids by lipases

Candida cylindracea lipase (CCL) and porcine pancreatic lipase (PPL) have been used for deacetylation of peracetates of methyl and ethyl esters of six different polyphenolic acids in organic solvents. Exclusive de-esterification of the ester groups derived from the phenolic hydroxy and aliphatic acid over the ester group of the aromatic acid and aliphatic alcohol has been achieved affording the corresponding esters of phenolic acids in as high yields as 90-97%. The results have been corroborated with the mechanism of lipase action.