7-<(3,4-dichlorophenyl)acetyl>-8-(1-pyrrolidinylmethyl)-7-aza-1,4-dioxaspiro<4.5>decane

Base Information

Chemical Name:7-<(3,4-dichlorophenyl)acetyl>-8-(1-pyrrolidinylmethyl)-7-aza-1,4-dioxaspiro<4.5>decane
CAS No.:125104-95-2
Molecular Formula:C₂₀H₂₆Cl₂N₂O₃
Molecular Weight:413.344
Hs Code.:

Synonyms:7-<(3,4-dichlorophenyl)acetyl>-8-(1-pyrrolidinylmethyl)-7-aza-1,4-dioxaspiro<4.5>decane

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Chemical Property of 7-<(3,4-dichlorophenyl)acetyl>-8-(1-pyrrolidinylmethyl)-7-aza-1,4-dioxaspiro<4.5>decane

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Technology Process of 7-<(3,4-dichlorophenyl)acetyl>-8-(1-pyrrolidinylmethyl)-7-aza-1,4-dioxaspiro<4.5>decane

There total 6 articles about 7-<(3,4-dichlorophenyl)acetyl>-8-(1-pyrrolidinylmethyl)-7-aza-1,4-dioxaspiro<4.5>decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 138155-07-4
1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-3-piperidinone

: 107-21-1
ethylene glycol

: 125104-95-2
7-<(3,4-dichlorophenyl)acetyl>-8-(1-pyrrolidinylmethyl)-7-aza-1,4-dioxaspiro<4.5>decane

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 2h; Heating;
DOI:10.1021/jm00081a009

Reference yield:

: 58481-17-7
methyl 2-(hydroxymethyl)pyridine-4-carboxylate

: 125104-95-2
7-<(3,4-dichlorophenyl)acetyl>-8-(1-pyrrolidinylmethyl)-7-aza-1,4-dioxaspiro<4.5>decane

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / etheral HCl, SOCl₂ / 4 h / 0 - 20 °C

2: 64 percent / Et₃N / CH₂Cl₂ / 1.) -60 deg C, 1 h, 2.) RT, 72 h

3: 35 percent / H₂ / 5percent Rh/C / ethanol / 14 h / 70 °C / 3620.04 Torr

4: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, RT, 40 min, 2.) CH₂Cl₂, RT, 18 h

5: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 2 h, 2.) CH₂Cl₂

6: 67 percent / p-TSA / toluene / 2 h / Heating

With hydrogenchloride; thionyl chloride; oxalyl dichloride; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; 1,1'-carbonyldiimidazole; Rh on carbon; In ethanol; dichloromethane; toluene;
DOI:10.1021/jm00081a009

Reference yield:

: 125104-37-2
methyl 2-(1-pyrrolidinylmethyl)-4-pyridinecarboxylate

: 125104-95-2
7-<(3,4-dichlorophenyl)acetyl>-8-(1-pyrrolidinylmethyl)-7-aza-1,4-dioxaspiro<4.5>decane

Guidance literature:: Multi-step reaction with 4 steps

1: 35 percent / H₂ / 5percent Rh/C / ethanol / 14 h / 70 °C / 3620.04 Torr

2: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, RT, 40 min, 2.) CH₂Cl₂, RT, 18 h

3: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 2 h, 2.) CH₂Cl₂

4: 67 percent / p-TSA / toluene / 2 h / Heating

With oxalyl dichloride; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; 1,1'-carbonyldiimidazole; Rh on carbon; In ethanol; toluene;
DOI:10.1021/jm00081a009