2,2,2-trifluoro-1-(2-phenyl-4,5-dihydro-1H-pyrrol-3-yl)ethanone

Base Information

• Chemical Name: 2,2,2-trifluoro-1-(2-phenyl-4,5-dihydro-1H-pyrrol-3-yl)ethanone
• CAS No.: 952959-35-2
• Molecular Formula: C₁₂H₁₀F₃NO
• Molecular Weight: 241.213
• Mol file: 952959-35-2.mol

Synonyms:2,2,2-trifluoro-1-(2-phenyl-4,5-dihydro-1H-pyrrol-3-yl)ethanone

Chemical Property of 2,2,2-trifluoro-1-(2-phenyl-4,5-dihydro-1H-pyrrol-3-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trifluoro-1-(2-phenyl-4,5-dihydro-1H-pyrrol-3-yl)ethanone

There total 1 articles about 2,2,2-trifluoro-1-(2-phenyl-4,5-dihydro-1H-pyrrol-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-phenyl-1-pyrroline (700-91-4) + ethyl trifluoroacetate, (383-63-1) → 2,2,2-trifluoro-1-(2-phenyl-4,5-dihydro-1H-pyrrol-3-yl)ethanone (952959-35-2) + N-Trifluoroacetyl-4,5-dihydro-2-phenylpyrrole

Guidance literature:

2-phenyl-1-pyrroline; With lithium diisopropyl amide; In tetrahydrofuran; at 10 ℃; for 0.5h;

ethyl trifluoroacetate,; In tetrahydrofuran; at -30 ℃; Further stages.;

DOI:10.1007/s11172-007-0055-7

Reference yield: 97.0%

2,2,2-trifluoro-1-(2-phenyl-4,5-dihydro-1H-pyrrol-3-yl)ethanone (952959-35-2) → 4-(2-aminoethyl)-5-hydroxy-3-phenyl-5-trifluoromethyl-4,5-dihydroisoxazole

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; for 1h; Heating;

DOI:10.1007/s11172-007-0055-7

Reference yield: 92.0%

2,2,2-trifluoro-1-(2-phenyl-4,5-dihydro-1H-pyrrol-3-yl)ethanone (952959-35-2) + m-chlorophenylhydrazine hydrochloride (2312-23-4) → 4-(2-aminoethyl)-1-(3-chlorophenyl)-5-phenyl-3-trifluoromethyl-1H-pyrazole hydrochloride

Guidance literature:

With hydrogenchloride; acetic acid; for 0.5h; Heating;

DOI:10.1007/s11172-007-0055-7

upstream raw materials:

2-phenyl-1-pyrroline

ethyl trifluoroacetate,

Downstream raw materials:

2-phenyl-1-pyrroline